Home » Drug Information » FDA Approved Drugs » 1997
Medical Areas: Cardiology/Vascular Diseases | Endocrinology | Family Medicine
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Lexxel (enalapril maleate-felodipine ER)
The following drug information is obtained from various newswires, published
medical journal articles, and medical conference presentations.
Company: Astra Merck
Approval Status: Approved January 1997
Treatment Area: hypertension
Lexxel has been approved for the treatment of hypertension.
Lexxel (enalapril maleate-felodipine ER), combines the
complementary action of the most frequently prescribed angiotensin
converting enzyme (ACE) inhibitor Vasotec (enalapril maleate) and
the newer generation long-acting calcium channel blocker (CCB)
Plendil (felodipine). Lexxel is expected to be available in
pharmacies in March.
Lexxel is a fixed-dose combination product containing 5 mg
enalapril and 5 mg felodipine. The medication is indicated for the
treatment of hypertension in patients who fail to achieve adequate
control with either enalapril or felodipine monotherapy.
In general, treatment with Lexxel is well tolerated with any
adverse events being mild and transient. The most frequently
observed clinical adverse events occur with an incidence of one
percent or greater include headache, peripheral edema and
dizziness. As with other combination medications containing ACE
inhibitor component, Lexxel should be discontinues as soon as
pregnancy is detected.
Hypertension is commonly treated with a variety of individual
therapies. Of those treated, one out of two patients are prescribed
either an ACE inhibitor or a CCB. When ACE inhibitor or CCB
monotherapy falls, physicians often prescribe a combination of the
Often referred to as the silent killer, hypertension affects 50
million Americans and is responsible for more than 40,000 deaths
annually, according to the American Heart Association. Uncontrolled
hypertension has been linked to stroke, heart attack and heart
failure. Although the cause of 90-95 percent of cases of
hypertension is unknown, the disease can be easily detected and
controlled with medication. Despite available treatments, recent
public health surveys suggest that only about one in five Americans
with hypertension have their blood pressure adequately