Home » Drug Information » FDA-Approved Drugs » 1996
Medical Areas: Cardiology/Vascular Diseases
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Drug Information
The following information is obtained from various newswires, published
medical journal articles, and medical conference presentations.
Company: Boehringer Mannheim Corporation
Approval Status: Approved November 1996
Treatment Area: patients suffering from heart attack
Retavase (reteplase), a new thrombolytic agent to help treat the
1.5 million American subjects suffering from heart attack each
year, has been approved. Retavase is the only thrombloytic that can
be given in a simple two-shot form rather than a continuous
intravenous infusion.
An international study of more than 6,000 subjects treated with
either Retavase or streptokinase proved Retavase to be safe and
effective in reducing mortality and lowering the incidence of CHF
and other cardiovascular conditions. Additionally, clinical data
show that Retavase was associated with a reduced need to perform
emergency angioplasty compared to Alteplase.
Thrombolytic agents are used to treat patents that suffer from
heart attack, or what is medically known as acute myocardial
infarction (AMI). Widespread research has shown that one of the
most effective treatments for a heart attack as a result of
blockage caused by a blood clot is to quickly administer a
thrombolytic agent to restore blood flow to the affected
artery.