FDA Approved Drugs » 2012
Medical Areas: Endocrinology | Gastroenterology | Hematology | Musculoskeletal | Family Medicine | Genetic Disease
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The following drug information is obtained from various newswires, published
medical journal articles, and medical conference presentations.
Approval Status: Approved May 2012
Treatment Area: Gaucher disease
Elelyso (taliglucerase alfa) is a hydrolytic lysosomal glucocerebroside-specific enzyme that functions as a long-term enzyme replacement therapy (ERT).
Elelyso is specifically indicated for the treatment of Type 1 Gaucher disease in adults.
Elelyso is supplied as an infusion designed for intravenous administration. The recommended initial dose of the drug is 60 units/kg administered every other week for 60-120 minutes. Dosage adjustments may be made based on achievement and maintenance of particular therapeutic goals.
FDA ApprovalFDA Approval of Elelyso was based on the results of two 9 month multi-center trials.Trial OneThis double-blind, randomized study enrolled 31 adults with Gaucher disease-related enlarged spleens and thrombocytopenia who were ERT-naïve. Sixteen subjects had enlarged livers and 10 had anemia at baseline. Subjects were randomized to be treated with Elelyso doses of either 30 units/kg (n=15) or 60 units/kg (n=16). The primary endpoint of change in spleen volume (SD) was observed in MRI at nine months measured by mean % body weight (%BW) and multiples of normal (MN) spleen volumes. Liver volumes and hemoglobin concentrations were also monitored. Subjects in the 30 units/kg and treatment arm demonstrated changes of -0.9 (0.4) %BW mean (SD) and -4.5 (2.1) MN mean (SD). Subjects treated with 60 units/kg demonstrated changes of -1.3 (1.1) %BW mean (SD) and -6.6 (5.4) MN mean (SD).Trial TwoThis open-label single arm study enrolled 25 subjects with Type 1 Gaucher disease who were switched to Elelyso from a 2-year minimum treatment duration of imiglucerase. Subjects were clinically stable and were administrered a stable biweekly dose of imiglucerase for
at least 6 months prior to enrollment. Elelyso was administered at the same dosage level as the previous imiglucerase treatment, 11 units/kg to 60 units/kg biweekly. Organ volumes and hemotologic values remained stable on average during the 9 month treatment period.
Adverse reactions associated with the use of Elelyso may include, but are not limited to, the following:
Elelyso (taliglucerase alfa) is a recombinant form of human Glucocerebrosidase (GCD). It is a lysosomal glucocerebroside-specific enzyme that catalyzes the hydrolysis of glucocerebroside to glucose and ceramide. Subjects with Gaucher disease do not produce enough GCD, which leads to the accumulation of glucocerebroside in the spleen, liver, and bone marrow.
For additional information regarding the use of Elelyso or Gaucher disease, please visit the Elelyso web page.
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