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Lupus Clinical Trials

New Medical Therapies™

Proteinuria

Patient Medical Areas

October 22, 2007

Exelixis released negative results from a phase II trial of XL784 for the treatment of proteinuria. This randomized, placebo-controlled study enrolled 130 diabetic subjects with clinically significant proteinuria. The subjects received 200 mg XL784 or placebo daily for 3 months. The primary endpoint of the trial was a significant reduction in proteinuria compared with placebo. Secondary endpoints included changes in renal function and cardiovascular events. While the treatment was determined to be safe and well tolerated, the primary endpoint was not accomplished. Exelixis plans to fully analyze the data in order to determine a future course of development for XL784.

This information does not represent a Lupus Research Institute endorsement of any listed study. It is merely a notice that the study is available. If you are presently under the care of a physician for lupus or other conditions, you should not disrupt your current program without discussing it with your doctor(s). Do not contact the Lupus Research Institute for information on these studies. Only contact the listed numbers. The Lupus Research Institute does not have any jurisdiction over or further involvement with these studies, other than to make people aware that they are being conducted.