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Affective Disorders

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April 4, 2005

Saegis Pharmaceuticals reported positive results from a phase I trial investigating SGS518, a selective antagonist of the 5-HT6 serotonin receptor for the treatment of Cognitive Impairment Associated with Schizophrenia (CIAS). The drug is thought to enhance brain chemical transmission. Clinical results found the drug to be safe and well tolerated. The placebo-controlled, blinded study enrolled healthy subjects who were dosed in two cohorts: a single-dose, dose-ranging arm, followed by a multi-dose arm. The study’s primary objective was to evaluate the safety, tolerability and pharmacokinetics of SGS518. Saegis is developing SGS518 in partnership with Eli Lilly.