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Lupus Clinical Trials

New Medical Therapies™

Chronic Pelvic Pain

May 23, 2011

Watson Pharmaceuticals released results from a phase II trial of Rapaflo for non-bacterial chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). This double-blind, 12-week, placebo-controlled trial enrolled 151 subjects with moderate to severe CP/CPPS who had not received treatment. The subjects were randomized to Rapaflo 4 mg or 8 mg per day, or placebo for 12 weeks. The primary measure of efficacy was improvement in the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scale after 12 weeks. Rapaflo 4 mg significantly decreased the total score versus placebo on quality of life measures (P≡0.0224) and urinary symptoms (P≡.0102). In addition, Rapaflo 4 mg showed significantly better results relative to placebo on the physical component of the 12-Item Short Form Health Survey (P≡.049) and in a global response assessment, 56% of subjects versus 29% of subjects receiving placebo reported moderate or marked improvement (P≡ 0.0069). An increase in dose to 8 mg resulted in no incremental increased effect. No unexpected adverse events were reported.

This information does not represent a Lupus Research Institute endorsement of any listed study. It is merely a notice that the study is available. If you are presently under the care of a physician for lupus or other conditions, you should not disrupt your current program without discussing it with your doctor(s). Do not contact the Lupus Research Institute for information on these studies. Only contact the listed numbers. The Lupus Research Institute does not have any jurisdiction over or further involvement with these studies, other than to make people aware that they are being conducted.