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Lupus Clinical Trials

New Medical Therapies™

Chronic Bronchitis

October 17, 2005

Oscient Pharmaceuticals has announced positive results of phase III trials of Factive (gemifloxacin mesylate) tablets, for the treatment of acute bacterial sinusitis (ABS) and acute bacterial exacerbations of chronic bronchitis (AECB). Pooled retrospective results from their phase III ABS program indicated that Factive was significantly superiority to approved therapies (cefuroxime and trovafloxacin) in both clinical success at end of therapy (89.3% vs. 77%; p=0.01) and in clinical success at follow-up (79.9% vs. 66.3%; p=0.019). Pooled data from the company's 10 AECB trials indicated non-inferiority of clinical response compared to a number of approved therapies (including clarithromycin, levofloxacin, trovafloxacin, amoxicillin-clavulanate, ceftriaxone/cefuroxime and ofloxacin). Factive is currently approved to treat AECB and community-acquired pneumonia; in is still under investigation for ABS.

This information does not represent a Lupus Research Institute endorsement of any listed study. It is merely a notice that the study is available. If you are presently under the care of a physician for lupus or other conditions, you should not disrupt your current program without discussing it with your doctor(s). Do not contact the Lupus Research Institute for information on these studies. Only contact the listed numbers. The Lupus Research Institute does not have any jurisdiction over or further involvement with these studies, other than to make people aware that they are being conducted.