Clinical Trials Resource Center

Tourette's Syndrome

July 30, 2012

Psyadon Pharmaceuticals issued results from a phase II trial of ecopipam for the treatment of Tourette’s syndrome. This eight-week, multi-center, open-label, non-randomized study enrolled 15 patients with moderate to severe Tourette’s syndrome. Subjects received ecopipam 50mg/day for the first two weeks and then 100mg/day for the remaining six weeks. The results showed a statistically significant (p<0.001) reduction in the total tic severity scores of the Yale Global Tic Severity Score, a well-validated rating scale typically used in Tourette’s trials. This effect was seen in the analysis of both patients who completed all visits (completer analysis; n=12) and all enrolled patients (intent-to-treat analysis; n=15). The study was stopped early when a planned interim analysis revealed a statistically significant reduction in the severity of the patients’ tic symptoms. Ecopipam was well tolerated. The most frequent adverse events were fatigue, nausea, sedation, headache, restlessness and sleeplessness. Psyadon is eager to move ecopipam into phase III trials.

This information does not represent a Lupus Research Institute endorsement of any listed study. It is merely a notice that the study is available. If you are presently under the care of a physician for lupus or other conditions, you should not disrupt your current program without discussing it with your doctor(s). Do not contact the Lupus Research Institute for information on these studies. Only contact the listed numbers. The Lupus Research Institute does not have any jurisdiction over or further involvement with these studies, other than to make people aware that they are being conducted.