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Therapeutic Areas: Cardiology/Vascular Diseases
Disease Category: Peripheral Arterial Occlusive Disease

Trial Information

Genetic Determinants of Peripheral Arterial Disease

The role of genetics, (which are traits that you inherit, such as your eye color or hair color), in determining whether patients with coronary artery disease also have circulation problems in the legs needs to be evaluated. The purpose of this research study is to identify genetic factors in peripheral arterial disease, study the interaction between environmental and genetic factors in the causes and worsening of the disease, and identify factors that cause differences in the severity of the vascular disease in different parts of the body. This study will involve evaluating 2,000 patients, 1,000 at Mount Sinai Medical Center and 1,000 at Stanford University over the course of five years. This study involves three questionnaires, measuring blood pressures in the arms and legs and the collection of blood samples for clotting factors and genetic analysis. It takes approximately 2 hours to complete this study.
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Patient Inclusion/Exclusion Criteria:

1. Patients who are scheduled for a non-emergent cardiac catheterization
2. Patients who have coronary artery disease confirmed by a heart catheterization.
3. Patients who can understand and sign the informed consent form.
4. Patients over age 40.

1. Pregnant women
2. Minors.
3. Mentally handicapped patients who cannot understand and sign the informed consent.

Patricia M. Mcmullen, Nurse Practitioner
Mount Sinai Medical Center
One Gustave L. Levy Place

New York, NY 10029
Phone: 212 241-0740
Fax: 212-410-7196
EMail: patricia.mcmullen@msnyuhealth.org

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