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Therapeutic Areas: Psychiatry/Psychology | Pediatrics/Neonatology
Disease Category: Obsessive-Compulsive Disorders
Trial Information
Ziprasidone augmentation in serotonin reuptake inhibitor-resistant Obsessive-Compulsive Disorder
The purpose of this study is to determine whether the medication
ziprasidone (Geodon) added to a serotonin reuptake inhibitor (SRI)
is effective in the treatment of patients who have previously
experienced little or no response to SRI treatment of
Obsessive-Compulsive Disorder. Ziprasidone is approved by the Food
and Drug Administration (FDA) for the treatment of schizophrenia,
but not approved for the symptoms associated with
obsessive-compulsive disorder. Study volunteers will be randomly
assigned to receive either ziprasidone or placebo (sugar pill) in
addition to their SRI for a period of 8 weeks. Study volunteers
will have a 50% chance of being given active medication.
Assessments included in the study will be: a psychiatric and
medical evaluation, lab tests (physical exam, routine blood test,
urinalysis, urine drug screen, an electrocardiogram (EKG) and a
blood pregnancy test (females only).) Participants will be closely
monitored throughout the study by a psychiatrist. GCO#
02-0150
No Compensation Provided
Patient Inclusion/Exclusion Criteria:
Men and women aged 18 - 65 years who have had little or no
response to more than 1 prior trial with an SRI will be eligible to
enter the program. Study volunteers should have a primary diagnosis
of Obsessive-Compulsive Disorder and should be physically healthy
without any serious medical, psychiatric, or neurological illnesses
other than OCD. Study volunteers should be stable on an SRI for at
least 3 months prior to enrollment.
Study volunteers should not be on any other forms of psychiatric
medication other than an SRI; those on other medications must be
willing to come off their medication. Please contact the Study
Coordinator below for further exclusion criteria.
Suah Kim
Mount Sinai Medical Center
One Gustave L. Levy Place
New York, NY 10029
Phone: 212-659-8732
Fax: 212-987-4031
EMail: suah.kim@mssm.edu
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If you would like to learn more about participating in this study, please send an e-mail message using the form below.
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