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Therapeutic Areas: Psychiatry/Psychology
Disease Category: Post-Traumatic Stress Disorders

Trial Information

Biology of Risk and PTSD in Holocaust Survivor Offspring

Our research explores the relationship between physical and mental symptoms in Holocaust offspring and their parents. Our earlier studies have pointed to the possibility that offspring may be at greater risk for the development of posttraumatic stress disorder and or depression if one or both of their parents also suffered from these conditions following their experiences in the Holocaust. In addition to asking offspring (and if possible, their parents) about their symptoms, we will also be able to perform biologic examinations on them. Because the study involves the collection of blood samples, participants will receive a medical evaluation after they sign informed consent and prior to participating in the studies. These tests are done to rule out major medical illnesses that would prevent participation. Medically eligible participants will be interviewed for several hours about events they have experienced as well as symptoms.
Compensation Provided

Patient Inclusion/Exclusion Criteria:

Jewish adult offspring of Holocaust survivors, or Jewish adults who do not have a parent who experienced the Holocaust as comparison subjects. Participants must have the ability to understand the protocol and are willing to provide written informed consent, were raised by biological parents until age 18, and born after 1946. (Although no younger age limit is specified, we anticipate that the majority of subjects are older than 30 years of age.)

Current diagnosis of a psychotic disorder, current substance/alcohol abuse or dependence (within the past 6 months). Any chronic conditions such as asthma, diabetes, high blood pressure, thyroid problems, seizures, surgeries, radiation or chemotherapy; any history of severe head trauma. Non-stabilized diabetes, renal, thyroid, or hepatic disease, other central nervous system disorders such as Parkinsons, active cardiac illness, or recent myocardial infarction in the last 6 months, will be excluded. Heavy smoking (i.e., more than 1 pack per day) or obesity will also exclude someone from participating. Use of some medications may exclude someone from participating, including any oral, inhaled, or eye drop steroid.

William Blair
Mount Sinai Medical Center
One Gustave L. Levy Place

New York, NY 10029
Phone: 718-584-9000 Ext. 6589
Fax: 718-741-4775
EMail: william.blair@med.va.gov

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