Research Study Summary
Effects of Enteral Glutamine Supplementation on Mortality and Infectious Morbidity in Severely Burned Patients: a Multi-center Pilot Trial
Enteral glutamine has been found to decrease mortality in critically ill patients and blood infection in trauma patients.
In our pilot study (Critical Care Medicine, 2003, 31:2444) we found the same protective effect of glutamine against blood infection in severely burned adult patients. In addition, a significant decrease in mortality was observed with glutamine. These results should be tested with a multi-center trial because our study was small and did not have mortality as an end point. Since such a large multi center study has never been conducted in burn patients, a pilot study that will test its feasibility seems warranted.
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CW ID: 222887
Date Last Changed:
February 2, 2017
Clinical Trial Snapshot
- Both Male and Female
- 18 and up
- Overall Status
- Queen's University
- Facility Type
- Deep 2nd and/or 3rd degree burns requiring grafting
- a.) Patients 18 - 59 years of age without inhalation injury TBSA* = 20% b.) Patients 18 - 59 years of age with inhalation injury TBSA* = 15% c.) Patients = 60 years of age (with or without inhalation injury) TBSA* = 10%
*TBSA - Total Burn Surface Area
- 72 hrs from admission to ICU to time of consent.
- Patients younger than 18 years of age
- In patients without known renal disease, renal dysfunction defined as a serum creatinine >171 µmol/L or a urine output of less than 500 ml/last 24 hours (or 80 ml/last 4 hours if a 24 hour period of observation is not available). In patients with acute on chronic renal failure (pre-dialysis), an absolute increase of >80 µmol/L from baseline or pre-admission creatinine or a urine output of <500 ml/last 24 hours (or 80 ml/last 4 hours) will be required. Patients with chronic renal failure on dialysis will be excluded.
- Liver cirrhosis - Child's class C liver disease
- Absolute contra-indication for EN: intestinal occlusion or perforation, abdominal injury
- Patients with injuries from high voltage electrical shock
- Patients who are moribund
- Patients with extreme body sizes: BMI < 18 or > 50
- Enrolment in another industry sponsored ICU intervention study
- Received glutamine supplement for > 24 hrs prior to randomization
- Known allergy to maltodextrin, corn starch, corn, corn products or glutamine
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