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Therapeutic Areas: Neurology | Family Medicine
Disease Category: Alzheimer's Disease
Location: United States, FL

Clinical Trial Details

Overview

Research Study Summary

A Phase III, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Efficacy and Safety Study of Crenezumab in patients with prodromal to mild Alzheimer's Disease.

Purpose

Alzheimer’s disease (AD) is the most common cause of dementia. The deposition of extracellular amyloid plaques in the brain is a hallmark pathological finding in AD. These amyloid plaques are primarily composed of Aβ peptides. This study is to evaluate crenezumab, a monoclonal antibody, that has been shown to inhibit self-association and aggregation of Aβ peptides.

To Learn more

CW ID: 216051
Date Last Changed: June 14, 2016

Clinical Trial Snapshot

Phase
3
Gender
Both Male and Female
Age
50 to 85 Years
Overall Status
Recruiting
Lead Sponsor
Genetech
Duration
100 Weeks
Facility Type
N/A

Eligibility

Inclusion Criteria:
  • Weight between 40 and 120 kg, inclusive
  • Patient meets NIAAA core clinical criteria for probable AD dementia or prodromal AD
  • Evidence of the AD pathological process, by a positive amyloid assessment either on CSF Aβ1−42 levels as measured on the Elecsys β-Amyloid(1-42) Test System OR amyloid PET scan by qualitative read by the core/central PET laboratory.
  • Demonstrated abnormal memory function at screening
  • Evidence of retrospective decline .

Contact

Jill Smith
University of South Florida - USF Health Byrd Alzheimer's Institute
4001 Fletcher Avenue
Tampa, FL 33613
Phone: 813-974-1294

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