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Therapeutic Areas: Oncology | Hematology
Disease Category: Chronic Lymphocytic Leukemia
Location: United States, WA
A Phase I/II Study of Fludarabine, Cyclophosphamide, Rituximab, and Vorinostat Followed by Rituximab and Vorinostat Maintenance Therapy in Patients With Previously Untreated B-Cell Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)
This phase I/II trial is studying the side effects and best dose of vorinostat when given together with fludarabine phosphate, cyclophosphamide, and rituximab and to see how well it works in treating patients with previously untreated B-cell chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Vorinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as fludarabine phosphate and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as rituximab, can block the growth of cancer in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Giving vorinostat together with fludarabine phosphate, cyclophosphamide, and rituximab may kill more cancer cells.
Patient Inclusion Criteria:
Patient Exclusion Criteria:
CW ID: 183326
Date Last Changed:
July 16, 2013
Christine Goetz, BA; CCRCMultiCare Health System314 Martin Luther King, Jr. Way, Suite 402Tacoma, WA 98405Phone: 253-403-7193
MultiCare Health System
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