Trial Information

MDA 2007-0194A Studying Biomarkers in Detecting Heart Damage in Patients Receiving Chemotherapy

RATIONALE: Studying samples of blood in the laboratory from patients receiving chemotherapy may help doctors identify and learn more about biomarkers related to heart damage due to chemotherapy. It may also help doctors plan the best treatment.

PURPOSE: This clinical trial is studying how well biomarkers work in detecting heart damage in patients receiving chemotherapy

Patients undergo physical exam, ECHO, EKG, and laboratory assessments, including measurement of B-type natriuretic peptide (BNP) and troponin I biomarkers, at baseline and periodically for up to 12 months. Patients also complete the M.D. Anderson Symptom Index-Heart Failure questionnaire at baseline and periodically for up to 12 months. Patients with an identified cardiac event, suspected cardiotoxicity, or abnormal biomarkers are referred to a cardiologist for treatment.

After completion of chemotherapy, patients are followed up at 6 and 12 months

Patient Inclusion Criteria:

Patients receive anthracycline-based chemotherapy for approximately 8 courses.
Ages Eligible for Study: 18 Years to 85 Years
Genders Eligible for Study: Both
Accepts Healthy Volunteers: No
Planning to start a new course of chemotherapy that includes an anthracycline
Does not have to be first-line therapy
B-type natriuretic peptide (BNP) < 200 pg/mL
Troponin I < 0.4 ng/mL
Life expectancy > 12 months
LVEF ≥ 50%

Patient Exclusion Criteria:

No unstable angina within the past 3 months
No myocardial infarction within the past 3 months
No decompensated heart failure within the past 3 months
No pre-existing or prior symptomatic arrhythmia within the past 3 months
No severe pulmonary disease (FEV ≤ 1.0 L)
No pulmonary hypertension (mean pulmonary artery pressure ≥ 60 mm Hg)
Not dependent on oxygen

Janeen V. Bazan, RN OCN BSN CCRP, Oncology Research Nurse Program Coordinator
Sherman Health
1425 North Randall Road
Elgin, IL 60123
Phone: 224-783-2907
Fax: 224-783-3071
Email: janeen.bazan@shermanhospital.org

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Research Center Information: Sherman Health

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