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Therapeutic Areas: Oncology | Hematology | Musculoskeletal
Disease Category: Leukemia
Location: United States, IL

Clinical Trial Details

Overview

Research Study Summary

ECOG E2903 Phase II Trial of Pentostatin, Cyclophosphamide and Rituximab (PCR) Followed By Campath-1H For Previously Treated Relapsed or Refractory Patients With Chronic Lymphocytic Leukemia

Purpose

The purpose of this study is to determine whether patients who have been previously treated for this disease can achieve a remission and whether their length of the remission will be increased with CAMPATH-1H treatment

Patient Inclusion Criteria:

  • Patients must have a diagnosis of B-CLL, as defined by the NCI criteria below (2).
  • All three criteria must be met:
    1. Patients must have a peripheral blood absolute lymphocyte count of > 5,000/mm3 obtained within 2 weeks prior to registration
    2. Count: Date of Test: The lymphocytosis must consist of small to moderate size lymphocytes, with < 55% prolymphocytes, atypical lymphocytes, or lymphoblasts morphologically.
    3. Patients must have phenotypically characterized B-CLL defined as: 1) the predominant population of cells share B-cell antigens with CD-5 in the absence of other pan-T-cell markers (CD-3, CD-2, etc.); 2) B-cell expresses either κ and λ light chains; and 3) surface immunoglobulin (slg)

Patient Exclusion Criteria:

  • Patients with grade III or IV heart failure according to the New York Heart Association functional classification are not eligible
  • Patients whose marrow function is attributable to dysplasia related to prior therapy are not eligible

To Learn more
Phase

2

Gender

Both Male and Female

Age

N/A

Overall Status

Recruiting

Facility Type

N/A

Contact

Janeen V. Bazan, RN OCN BSN CCRP, Oncology Research Nurse Program Coordinator
Sherman Health
1425 North Randall Road
Elgin, IL 60123
Phone: 224-783-2907
Fax: 224-783-3071

View Map

Research Center Information: Sherman Health

If you would like to learn more about participating in this research study, please email the trial contact using the form below.

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CW ID: 183146

Date Last Changed: July 17, 2013


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