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Therapeutic Areas: Neurology | Musculoskeletal | Family Medicine
Disease Category: Parkinson's Disease
Location: United States, NC

Clinical Trial Details


Research Study Summary

N.O.H. - A study for Parkinson's Disease patients with symptomatic low blood pressure.


The purpose of this research study is to determine whether Droxidopa can relieve the symptoms of neurogenic orthostatic hypotension (NOH) and whether it causes any side effects in people with symptomatic NOH.

Patient Inclusion Criteria:

  • 18 years old
  • clinical diagnosis of Parkinson's disease
  • clinical diagnosis of symptomatic neurogenic orthostatic hypotension
  • written informed consent

Patient Exclusion Criteria:

  • Concomitant use of vasoconstricting agents for the purpose of increasing blood pressure
  • Concomitant use of anti-hypertensive medication for the treatment of essential hypertension
  • known or suspected alcohol or substance abuse within the past 12 months
  • women who are pregnant or breast feeding
  • closed angle glaucoma
  • uncontrolled cardiac arrhythmia
  • myocardial infarction within the past 2 years
  • unstable angina
  • congestive heart failure
  • diabetic autonomic neuropathy
  • history of cancer within the past 2 years
  • ulcerative colitis or gastric bypass
  • any major surgical procedure within 30 days of baseline
  • previously treated with droxidopa
  • currently receiving any investigational drug
  • any condition or lab test result, which in the Investigator's judgement might result in an increased risk to the patient, or would affect their participation in the study. Additionally the Investigator has the ability to exclude a patient if for any reason they feel the subject is not a good candidate for the study or will not be able to follow study procedures.

To Learn more



Both Male and Female


18 and up

Overall Status


Facility Type



Guilford Neurologic Associates
912 Third Street, Suite 101
Greensboro, NC 27405
Phone: 336-275-8671

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Research Center Information: Guilford Neurologic Associates

CW ID: 182131

Date Last Changed: July 18, 2013

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