Trial Information

Phase II Trial of Neoadjuvant Chemotherapy with Carboplatin and NAB-Paclitaxel in Patients with Locally Advanced and Inflammatory Triple Negative Breast Cancer

You are being asked to take part in this study because you have locally advanced breast cancer (LABC) or inflammatory breast cancer (IBC) that cannot be cured by surgery alone or because your doctor believes that it is best to give you chemotherapy to shrink your tumor before surgery. The term locally advanced breast cancer (LABC) is used to describe a breast cancer that has progressed locally but has not yet spread outside the breast and local lymph nodes. Inflammatory breast cancer (IBC) is a specific type of locally advanced breast cancer. The purpose of this trial is to evaluate the effectiveness of drugs carboplatin and nab-paclitaxel in the treatment of breast cancer prior to surgery in terms of the amount of tumor remaining at the time of surgery and the side effects of this combination of drugs. Researchers will also be looking at the genetic and protein makeup of tumor tissue and blood samples collected before, during and after treatment to define prognosis (expected outcome), evaluate changes that occur during treatment and identify potential future targets of therapy.

Your participation in this study is expected to last up to 16 weeks. Patients will be followed for an indefinite period of time after enrollment.

Patient Inclusion/Exclusion Criteria:

- See http://clinicaltrials.coh.org for additional information.

City of Hope
1500 East Duarte Road
Duarte, CA 91010-3000
Phone: 866-896-HOPE (4673)

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Research Center Information: City of Hope

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