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Therapeutic Areas: Oncology | Hematology
 Disease Category: Acute Myelogenous Leukemia (AML)
Location: United States, CA

Trial Information

A Phase I Study of 5-Fluoro-2-deoxycytidine with Tetrahydrouridine (FdCyd + THU) in Myeloid Leukemia and MDS

You have been asked to participate in this research study because you have acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The purposes of this study are: (a) to determine the highest safe dose of 5-Fluoro-2'-Deoxycytidine with Tetrahydrouridine (FdCyd and THU) in patients with your disease, (b) to evaluate whether treatment with FdCyd and THU alters DNA methylation patterns (processes in cells related to the development of cancer) in blood cells, including leukemia and dysplastic cells, (c) to measure changes in red blood cell precursors (immature cells that will develop into normal red blood cells that circulate in the blood and carry oxygen) during treatment, and (d) to save samples of blood and bone marrow for future studies of how treatment alters immune response. Your treatment on this study may last as long as the study treatment appears to be benefiting you and you are not experiencing unmanageable side effects. After your treatment on this study is over, your medical condition will be followed indefinitely.

Patient Inclusion/Exclusion Criteria:


- See http://clinicaltrials.coh.org for additional information.


City of Hope
1500 East Duarte Road
Duarte, CA 91010-3000
Phone: 866-896-HOPE (4673)

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Research Center Information: City of Hope

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