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Therapeutic Areas: Nephrology | Family Medicine
Disease Category: Kidney Disease
Location: United States, NY

Clinical Trial Details

Overview

Research Study Summary

Alkali Therapy in Chronic Kidney Disease

Purpose

The purpose of this study is to determine the effect of oral sodium bicarbonate on muscle strength and function, bone breakdown, insulin resistance, and kidney damage in people with chronic kidney disease. Interested individuals will come in for a visit to learn about the study and to determine eligibility. If eligible, participants will be randomly assigned to receive either sodium bicarbonate pills or placebo pills for a duration of 2 years. Participants will perform tests of muscle strength and will have measurements of bone density, as well as insulin sensitivity and kidney function. Those interested may be eligible for further testing of muscle function and responsiveness to insulin.

Patient Inclusion Criteria:

  • Age is greater than 18 years
  • Those who have kidney disease (specifically, an estimated GFR = 45 ml/min/1.73m2 and >15 ml/min/1.73 m2)

Patient Exclusion Criteria:

  • Chronic treatment with alkali within the last 3 months (including sodium bicarbonate or baking soda)
  • Bicarbonate levels of less than 20 or greater than 25 mEq/L
  • New York Heart Association Class III or IV heart failure
  • Systolic blood pressure greater than 180 mm Hg
  • Kidney transplantation
  • Treatment with immunosuppressives with the last 3 months

To Learn more
Gender

Both Male and Female

Age

18 and up

Overall Status

Recruiting

Facility Type

N/A

Contact

Lisandra Niñonuevo, Study Coordinator
The Harold & Muriel Block Institute for Clinical and Translational Research at Einstein & Montefiore
Clinical Research Center
1300 Morris Park Avenue
Forchheimer Building, Room G47
Bronx, NY 10461
Phone: 718-430-3301

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If you would like to learn more about participating in this research study, please email the trial contact using the form below.

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CW ID: 179633

Date Last Changed: July 19, 2013


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