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Therapeutic Areas: Gastroenterology | Infections and Infectious Diseases | Family Medicine
Disease Category: Inflammatory Bowel Disease
Location: United States, NY
Inflammatory Bowel Disease Exacerbation and Changes in Gut Microbiome and Innate Immunity
The researchers at the Rockefeller University Hospitals are doing this research to understand how microbes (tiny organisms, bacteria) that are found in the stool and lining (mucosal membrane) of the lower part of the colon is different in individuals with stable and not stable inflammatory bowel disease (IBD) compared to healthy individuals.
IBD is a name given to a group of medical problems in which the lining of the intestines become red and swollen causing abdominal (stomach) pain and cramping, loose frequent stool (diarrhea), weight loss and loss of appetite. Two of the most common types of IBD are ulcerative colitis (UC) and Crohn’s disease. For this study, subjects with the UC form of IBD will be enrolled. The symptoms of UC can wax and wane (get worse and get better) in the intensity and severity of illness. When there is severe inflammation, the disease is considered to be in an "active stage", and the person experiences a flare-up of the condition. When the degree of inflammation is less (or absent), the person usually is without symptoms, and the disease is considered to be in "remission". Our study is designed to examine the natural setting of the microbes in your lower intestines (gut) and how they act in people with IBD in active stage disease, in those whose IBD is in remission and in healthy volunteers.
About 50 people will take part in the research study at the Rockefeller University Hospital. Participation is about 13 months long and includes:
- 1 to 2 sigmoidoscopies
- Providing monthly stool samples for 12 months
The research study as a whole will last about 2 years.
Patient Inclusion Criteria:
- Ages 18-65
- Confirmed diagnosis of Ulcerative Colitis
Patient Exclusion Criteria:
- IBD is currently in remission
- HIV positive
- History of a bleeding disorder
Clinical Research Support Office
The Rockefeller University Hospital
1230 York Avenue
New York, NY 10065
If you would like to learn more about participating in this study, please send an email message using the form below.
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