Clinical Trial Details


Research Study Summary

A Pilot Trial of Radiation Therapy "sandwiched" between Paclitaxel and Carboplatin in Patients with Uterine Carcinosarcoma


The purpose of this study is to determine whether radiation therapy "sandwiched" between paclitaxel/carboplatin chemotherapy is effective in the treatment of uterine carcinosarcoma,and particularly whether this treatment will lessen the chance of the cancer returning in the pelvis or elsewhere in the body.

Patient Inclusion Criteria:

  • Histologically documented uterine carcinosarcoma with no visible residual disease.
  • Surgical staging to include total abdominal hysterectomy, bilateral salpingo- oophorectomy, peritoneal washings, and lymph node samplings.
  • Patients must be entered no more than 12 weeks post operatively.
  • Age > 18 years.
  • ECOG performance status of < 2.
  • Written voluntary informed consent

Patient Exclustion Criteria:

  • Patient has impairment of hepatic, renal or hematologic function as defined by the following baseline laboratory values:
    • Serum SGOT and /or SGPT > 2.5 times the institutional upper limit of normal
    • Total serum bilirubin > 1.5 mg/dl
    • History of chronic or active hepatitis
    • Serum creatinine > 2.0 mg/dl
    • Platelets < 100,000/mm3
    • Absolute neutrophil count (ANC) < 1500/mm3
    • Hemoglobin < 8.0 g/dl (the patient may be transfused prior to study entry)
  • Patient has severe or uncontrolled concurrent medical disease (eg. uncontrolled diabetes, unstable angina, myocardial infarction within 6 months, congestive heart failure, etc.)
  • Patient with any prior chemotherapy or radiotherapy for pelvic malignancy.
  • Patients with dementia or altered mental status that would prohibit the giving and understanding of informed consent at the time of study entry.

To Learn more

CW ID: 176618
Date Last Changed: April 14, 2014

Clinical Trial Snapshot

18 and up
Overall Status
Facility Type


Loraine Centrilla, RN, Research Coordinator
The Harold & Muriel Block Institute for Clinical and Translational Research at Einstein & Montefiore
Montefiore Medical Center
1695 Eastchester Road Suite 601
Bronx, NY 10461
Phone: 718-405-8082

View Map

Volunteer for this Trial

If you would like to learn more about participating in this research study, please email the trial contact using the form below. We value your privacy and your information will only be used by the research center to contact you regarding this study.

DISCLAIMER: CenterWatch does not conduct clinical research. CenterWatch is a publishing company that posts clinical trials information on behalf of sponsor companies, contract research organizations, clinical research sites and other interested parties. This information is designed to help patients find clinical trials of interest and contact the research centers conducting the trials.