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Therapeutic Areas: Oncology
Disease Category: Non-Small Cell Lung Cancer

Trial Information

Chemotherapy and Radiation in Treating Patients With Stage 3 Non-Small Cell Lung Cancer (PROCLAIM)

This study will compare the overall survival of patients with locally advanced, Stage III Non-Small Cell Lung Cancer with nonsquamous cell histology.

Patient Inclusion Criteria:

• You must have Stage 3A or 3B Non-Small Cell Lung Cancer of the non-squamous type
• You must have measureable tumor lesions according to the Response Evaluation Criteria in Solid Tumors (RECIST) guidelines or disease that can be evaluated on CT scan
• You must at least be able to physically be mobile, take care of yourself and must be up and about and able to perform light activities such as light housework or office work
• 18 years of age or older
• You have lost no more than 5% of body weight in the previous three months
• Women must be sterile, postmenopausal or on contraception and men must be sterile or on contraception
• Your test results assessing the function of your blood forming tissue, kidneys, liver and lungs are satisfactory

Patient Exclusion Criteria:

• You cannot have other on-going illnesses including active infections, recent heart problems or psychiatric illnesses
• You are unable to take vitamins (including injections of vitamin B12) or oral cortisone medication
• You cannot have had a heart attack or other cardiac issues within 6 months of the trial
• You cannot have received other investigational drugs within the last 30 days
• You are unable to stop taking more than 1.3 grams of aspirin on a daily basis or non-steroidal anti-inflammatory agents.
• You cannot have had previous chest radiation, however, other prior radiation is allowed if it was at least 30 days prior to the trial and limited in extent.
• You cannot have a radiation treatment plan that would expose more than 35% of your unaffected lung to 20 Gy or more of radiation

Patricia Green Sharpe MSN MHSA RN, Director, Department of Clinical Trials/Oncology Data Services
Memorial Health University Medical Center
William & Iffath Hoskins Center for Biomedical Research & Education
4700 Waters Avenue
Savannah, GA 31404
Phone: 912 350-7887
Fax: 912 350-8183
EMail: sharppa1@memorialhealth.com

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