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Therapeutic Areas: Neurology
Disease Category: Migraine and Cluster Headaches

Trial Information

Chronic Migraine Research Study

Do you suffer from Chronic Migraines? If so, you may qualify for a research study testing two FDA approved medications for the treatment of migraines.

To Qualify you must:

• Be 18 years or older
• Have a history of chronic migraine for at least 6 months and are currently not taking any medications on a daily basis to prevent your migraines other than topiramate (Topamax)
• Be willing to take two daily medications for six months
• Be willing to keep daily 28-day headache diaries on four occasions during the study.

Criteria

Inclusion Criteria

• History of chronic migraine for at least 6 months
• Age ≥ 18 years and age of migraine onset 60 or younger
• EKG performed in the last 12 months

Exclusion Criteria

• Prior neuro-imaging suggesting secondary structural causes of headache
• Beck Depression Inventory FastScreen score of 13 or greater or other severe psychiatric disorder
• Contraindication to or prior intolerance of topiramate or propranolol (no history of sinus bradycardia, heart block, heart failure, diabetes prone to hypoglycemia, asthma, kidney stones)
• History of kidney failure or nephrolithiasis
• A female who is currently pregnant or lactating or planning to become pregnant in the next year, or is of child-bearing potential and not practicing an acceptable form of birth control
• Currently requires butalbital or opioid drugs for acute headache treatment 10 or more days a month
• Failure of prior trials with at least 50 mg of topiramate combined with at least 80 mg of propranolol
• Use of other migraine preventive drugs (Medications graded as groups 1, 2, 3, and 4 in the AAN Evidence-based Guideline: valproate, divalproex sodium, gabapentin, amitriptyline, nortriptyline, protriptyline, beta-blocker, calcium channel blocker, cyproheptadine; and tizanidine) within the last two months or has received botulinum toxin injection in the past 3 months

Review the informed consent form.

Annette M. Phillips, RN Direct
CNS Research of RI, Inc.
P.O. Box 603153
Providence, RI 02906
Phone: 800-707-6013

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