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Therapeutic Areas: Gastroenterology
Disease Category: Inflammatory Bowel Disease

Trial Information

Dysbiosis in inflammatory bowel disease.

The purpose of this research is to investigate the bacteria that lives in the intestines and colon of healthy individuals compared to persons experiencing IBD. Humans have bacteria that live and grow in the colon. These bacteria serve important purposes in the colon. They help to digest food and keep the colon healthy. However, while it is speculated that there is change in the bacterial composition in diseases like IBD, the specific changes are largely unknown. We would therefore like to study any change or alteration in the bacterial composition in persons with IBD as compared to healthy individuals. We hope this will allow us to identify acute changes in bacterial composition in patients suffering from IBD.

Patient Inclusion Criteria:

• Be 18 years of age or older;
• Have documented Ulcerative Colitis or Crohn’s disease;
• Have inactive IBD for at least 2 weeks;
• Be non- smokers or have no change in smoking habits a month prior to enrollment and during the study;
• Be born and raised in the U.S;
• Have stable weight with stable dietary habits over the last year;
• Have a BMI <30;

Patient Exclusion Criteria:

• extensive colonic or ileocolonic resection;
• concomitant infections (C. difficile colitis) or IBD flare (clinical or endosocopic) ;
• potential IBD exacerbators such as NSAIDs within 1 wk of the study;
• pre-existent organ failure or comorbidities (liver disease; kidney disease; uncontrolled psychiatric illness; lung disease; heart failure; HIV disease; alcoholism; transplant recipients; diabetes; obesity with BMI >30; short bowel syndrome;severe malnutrition);
• desire to become pregnant during study, be pregnant or nursing;
• use anticoagulats and antiplatelet medications.

Delia Daian, Research coordinator
Rush University Medical Center - Treatment Research Center
1725 W Harrison Street, Suite206
Chicago, IL 60612
Phone: 312-942-3644
Fax: 312-563-3821
EMail: delia_daian@rush.edu

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