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Therapeutic Areas: Cardiology/Vascular Diseases
Disease Category: Thrombosis
Trial Information
Study of Apixaban for the Prevention of Thrombosis-Related Events in Patients With Acute Medical Illness (ADOPT)
The purpose of this study is to learn if apixaban can prevent blood clots in the leg (deep vein thrombosis [DVT]) and lung (pulmonary embolism [PE]) that sometimes occur within patients hospitalized for acute medical illness, and to learn how apixaban compares to enoxaparin (Lovenox®) for preventing these clots. The safety of apixaban will also be studied.
Patient Inclusion Criteria:
- men and non-pregnant, non-breastfeeding women
- 40 years or older
- hospitalized with congestive heart failure or acute respiratory failure
- infection (without septic shock)
- acute rheumatic disorder
- inflammatory bowel disease
Patient Inclusion Criteria:
- patients with VTE
- active bleeding or at high risk of bleeding
- unable to take oral medication
- with diseases requiring ongoing treatment with anticoagulants or antiplatelets other than aspirin at a dose less than or equal to 165 mg/day
Kelly Colucci, Manager, Grants and Contracts
Atlantic Health System
475 South Street
Morristown, NJ 07962
Phone: 973-660-3139
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Research Center Information: Atlantic Health System
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