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Therapeutic Areas: Nephrology/Urology
Disease Category: Kidney Disease

Trial Information

The ACCESS Trial for lupus with kidney disease (lupus nephritis)

This study is for people with lupus who have developed complications in their kidneys (a condition called "lupus nephritis"). The study is testing whether adding the experimental medication called "abatacept" (pronounced ‘AB-uh-TA-sept) to a standard cyclophosphamide (Cytoxan) treatment regimen is more effective in improving lupus nephritis than the cyclophosphamide regimen by itself. The study drug abatacept has been approved by the FDA for the treatment of moderate to severe rheumatoid arthritis, however it is an experimental medication for lupus nephritis. Participation in the study will last for two years.

For more information:
www.lupusnephritis.org

The ACCESS trial is sponsored by the National Institute of Allergy and Infectious Diseases (a part of the National Institutes of Health) and is being conducted by the Immune Tolerance Network, a non-profit consortium of doctors and scientists aiming to develop new treatments for immune-based disease.

If you meet the following criteria, you may be eligible to participate in the ACCESS trial:

• You are 16 years of age or older
• You have been diagnosed with systemic lupus erythematosus (SLE)
• You have active kidney disease (lupus nephritis)

Patient Exclusion:

• use of cyclophosphamide (Cytoxan) in the past year
• end stage renal disease
• neutropenia, thrombocytopenia, moderately severe anemia
• active infection, including HIV, hepatitis B or C
• history of cancer, except carcinoma in situ and treated basal and squamous cell carcinomas
• pregnant or breastfeeding

Sue Ellen Weigel
Children's Mercy Hospital
Located in:
Kansas City, MO 64108
Phone: 816-234-3975
EMail: kansascity@type1diabetestrial.org

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