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Therapeutic Areas: Oncology | Neurology
Disease Category: Brain Cancer

Trial Information

A Phase IIa Study of ADV-TK + Valacyclovir Gene Therapy in Combination with Standard Radiation Therapy for Malignant Gliomas

You have been asked to participate in this research study because you have malignant glioma (a brain tumor). The purpose of this study is to evaluate what side effects occur when AdV-tk (an experimental gene transfer treatment explained further in section II) is given in combination with valacyclovir and radiation therapy. The researchers will also look at the type of side effects the treatment causes and whether malignant glioma responds to this treatment and how long the response lasts. In addition, researchers will evaluate how this treatment impacts quality of life. Lastly, researchers will collect tumor tissue samples for future research studies and special blood samples for Immune Research Studies. Your participation in this study is expected to last 3-4 months for treatment. After your treatment on this study is over, your medical condition will be followed indefinitely.

Patient Inclusion/Exclusion Criteria:

- See http://clinicaltrials.coh.org for additional information.

City of Hope
1500 East Duarte Road
Duarte, CA 91010-3000
Phone: 866-896-HOPE (4673)

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