Skip Navigation

Advertise|Press|Contact|FAQ|About Us

Bookmark/Print/Share

Home » Clinical Trials » Therapeutic Areas
Therapeutic Areas: Oncology | Otolaryngology (Ear, Nose, Throat) | Pulmonary/Respiratory Diseases | Family Medicine
Disease Category: Esophageal Cancer
Location: United States, NJ

Clinical Trial Details

Overview

Research Study Summary

Barrett's Esophagus & Gastroesophageal Reflux Disease

Purpose

This is a study of Barrett's Esophagus (BE) and Gastroesophageal Reflux Disease (GERD). It aims to look at the long term efficacy of evidence-based cutting edge diagnostic and therapeutic algorithms and techniques such as radiofrequency ablation, endoscopic mucosal resection and surveillance endoscopy with biopsy. Additionally, biological analyses will be performed in hopes of identifying biomarkers associated with the progression of BE to esophageal cancer.

Inclusion Criteria:

  • Male or female, age 18 to 85.
  • Patient must have Barrett's Esophagus.
  • Patients may be enrolled based on previous endoscopy reports and/or pathology reports. It is not necessary that each patient have endoscopy for the sole purpose of enrollment.
  • Must agree to allow their clinical information to be collected, stored, analyzed and reported.
  • Must allow portions of their biopsy/surgical specimens to be collected, stored, analyzed and reported.
  • Must agree to fill out patient questionnaires in conjunction with the research study assistant assigned to this protocol (either in person or via telephone contact) at designated timepoints.

Patient Exclusion Criteria:

  • Intestinal metaplasia of the cardia, without an esophageal columnar lining.
  • Unable to provide informed consent.
  • Unable or unwilling to undergo endoscopic procedures.

Primary Outcomes:
Barrett's esophagus (BE) is a known premalignant condition of the esophagus, predisposing to the development of esophageal adenocarcinoma. BE represents a change in the lining (mucosa) of the esophagus which is known to be produced as a result of chronic gastroesophageal reflux. The current standard of care for patients with BE includes serial performance of upper endoscopy with multiple biopsies, performed at designated time intervals. However, the emergence of new technologies for the management of this condition has made the care of these patients non-uniform, and subject to biases of individual treating physicians.

The protocol at The Valley Hospital and Blumenthal Cancer Center aims to standardize the management of patients with Barrett's esophagus, with and without dysplasia, using evidence-based, cutting edge diagnostic and therapeutic algorithms and techniques such as radiofrequency ablation, endoscopic mucosal resection, and surveillance endoscopy with biopsies. If biopsies suggest the development of carcinoma or high grade dysplasia surgical removal of the esophagus is recommended. This study aims to look at the long-term efficacy of these procedures. In addition, data regarding clinical outcomes will be collected as well as blood, tissue and surgical specimens for proteomic analysis in hopes of identifying biomarkers associated with the progression of dysplasia to adenocarcinoma. Although patients will ultimately make their own informed decisions regarding the management of their BE, this protocol serves to unify physician recommendations, and allows for the collection and interpretation of data.

To Learn more
Gender

Both Male and Female

Age

18 to 85 Years

Overall Status

Recruiting

Facility Type

N/A

Contact

Sobeida J. Santana-Joseph, Disease Mgt Teams Coordinator
The Valley Hospital/Valley Health System
Daniel & Gloria Blumenthal Cancer Center
One Valley Health Plaza
Paramus, NJ 07652
Phone: 201-634-5567
Fax: 201-634-5383

View Map

Research Center Information: The Valley Hospital/Valley Health System

If you would like to learn more about participating in this research study, please email the trial contact using the form below.

Name:
Address:
City:
State:
Zip/Postal Code:
Country:
Phone:
Email:  
Message:
 
Please leave this field empty.

CW ID: 120691

Date Last Changed: July 25, 2013


DISCLAIMER: CenterWatch does not conduct clinical research. CenterWatch is a publishing company that posts clinical trials information on behalf of sponsor companies, contract research organizations, clinical research sites and other interested parties. This information is designed to help patients find clinical trials of interest and contact the research centers conducting the trials.