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Therapeutic Areas: Oncology | Otolaryngology (Ear, Nose, Throat)
Disease Category: Thymomas
Location: United States, NJ
Preoperative Treatment of Patients With High Risk Thymoma
This is a phase II study for patients with thymoma or thymic
carcinoma thought to be at significant risk for recurrence
following surgical removal. This study involves the use of combined
chemotherapy and radiation therapy prior to surgery, in hopes of
increasing the chances of complete resection. The chemoradiotherapy
protocol is one which has been used extensively for other diseases,
and the side effects are therefore well-documented. Patients with
thymomas thought to be at significant risk for recurrence (by x-ray
and pathology criteria) will be allowed to participate, and will
undergo combined chemotherapy with radiation to the chest followed
by surgical removal of the tumor and postoperative chemotherapy.
The main outcome measured will be the rate of pathological complete
response (e.g. no active tumor in the resected specimen) to the
preoperative treatment. Patients will receive postoperative
treatment based on surgical and pathologic criteria.
Ages Eligible for Study:
Genders Eligible for Study:
Patient Exclusion Criteria
To determine the complete pathologic response rate to peroperative
cisplatin and etoposide given concurrently with radiation in
patients with thymoma thought to be at high risk for
Key Secondary Outcomes:
CW ID: 120690
Date Last Changed:
July 25, 2013
Susan Mock, BSN, Study CoordinatorThe Valley Hospital/Valley Health System1 Valley Health PlazaParamus, NJ 07450Phone: 201-634-5793Fax: 201-634-5383
The Valley Hospital/Valley Health System
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