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Therapeutic Areas: Musculoskeletal
Disease Category: Bone Diseases
Location: United States, CA
COG D9902: A COG Soft Tissue Sarcoma Biology and Banking Protocol
You have/Your child has been asked to participate in this research study because you have/your child has symptoms of a cancer called Rhabdomyosarcoma (RMS) or Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS, including chordoma, desmoid fibromatosis, desmoplastic round cell tumors, malignant rhabdoid tumors and undifferentiated embryonal sarcoma of the liver) or other soft tissue neoplasm. In order to confirm this diagnosis, you are/your child is scheduled to have a sample of the tumor taken by a needle or by surgery.
The study has three main goals:
1) Experts in the diagnosis of soft tissue sarcomas will look at the tumor cells and do tests with the tumor tissue to determine the exact type of soft tissue sarcoma. Identifying the exact type of soft tissue sarcoma will help determine which treatment has the best chance of cure. It will also allow enrollment on one of the Children’s Oncology Group (COG) treatment studies for soft tissue sarcomas.
2) Soft tissue sarcoma, blood, and bone marrow specimens will be collected for research to learn more about RMS and NRSTS. This research may include DNA studies to identify changes in genetic information that may help explain what causes the tumor and why it does or does not respond to certain drugs. This information may help doctors predict which treatments will work best with which types of tumors. Some specimens will be banked and studied later when additional tests are developed.
3) To collect specimens for the COG soft tissue sarcoma tissue bank for future research.
The researchers would like to collect specimens when the tumor is found, whenever surgery is done, and when (and if) the tumor returns after treatment is over. If you/your child will not be enrolling on a treatment study, information will be collected from medical records about the treatment you/your child receive and your/your child’s medical outcome. If you are/your child is enrolled in a COG treatment study, information will be collected during your/your child’s treatment and your/your child’s follow-up visits, which are expected to last up to 10 years.
You/your child will be told the exact type of tumor you/your child has, and this will become part of your health record.
Patient Inclusion/Exclusion Criteria:
- See http://clinicaltrials.coh.org for additional information.
City of Hope
1500 East Duarte Road
Duarte, CA 91010-3000
Phone: 866-896-HOPE (4673)
Research Center Information: City of Hope
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