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Nashville, Tennessee Clinical Trials

A listing of Nashville, Tennessee clinical trials actively recruiting patient volunteers.

RESULTS

Found (20) clinical trials

A Study of TAS0728 in Patients With Solid Tumors With HER2 or HER3 Abnormalities

This is a First-in-Human (FIH), 2-part, Phase 1/2, open-label, multicenter study design to evaluate the safety, tolerability, PK, pharmacodynamics, PGx, and efficacy of TAS0728. This study consists of Phase 1 and Phase 2a components in subjects with advanced solid tumors with HER2 or HER3 overexpression, amplification, or mutation who have ...

Phase

1.3 miles

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An Investigational Immuno-therapy Study of Nivolumab Pomalidomide and Dexamethasone Combinations in Patients With Multiple Myeloma

The purpose of this study is to evaluate the safety and effectiveness of several combination therapies for Multiple Myeloma. Upon entry into the study, patients will be randomized (assigned by chance) to receive either: Group 1: nivolumab, pomalidomide and dexamethasone OR Group 2: pomalidomide and dexamethasone OR Group 3: nivolumab, ...

Phase

1.3 miles

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CAB-ROR2-ADC Safety and Efficacy Study in Patients With Solid Tumors

This is a multi-center, open-label, Phase 1/2 study designed to evaluate the safety, tolerability, PK, immunogenicity, and antitumor activity of BA3021, a conditionally active biologic (CAB) ROR2-targeted antibody drug conjugate (CAB-ROR2- ADC) in patients with advanced solid tumors. This study will consist of a dose escalation phase and a dose ...

Phase

1.3 miles

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A Study of Atezolizumab in Combination With Nab-Paclitaxel Compared With Placebo With Nab-Paclitaxel for Participants With Previously Untreated Metastatic Triple-Negative Breast Cancer (IMpassion130)

This multicenter, randomized, double-blind study will evaluate the efficacy, safety, and pharmacokinetics of atezolizumab (MPDL3280A) administered with nab-paclitaxel compared with placebo in combination with nab-paclitaxel in participants with locally advanced or metastatic triple-negative breast cancer (TNBC) who have not received prior systemic therapy for metastatic breast cancer (mBC). The safety ...

Phase

1.3 miles

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Platform Study for the Treatment of Relapsed or Refractory Aggressive Non-Hodgkin's Lymphoma (PRISM Study)

This is a Phase 1 platform protocol designed to evaluate various targeted agents for the treatment of relapsed/refractory aggressive Non-Hodgkin's lymphoma (NHL). Each study arm will be conducted in a predefined disease subset. All study arms are open label and allocation to each study arm will not be randomized. As ...

Phase

1.3 miles

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A Study of the Efficacy and Safety of Atezolizumab Plus Chemotherapy for Patients With Early Relapsing Recurrent Triple-Negative Breast Cancer

This study will evaluate the efficacy and safety of atezolizumab plus chemotherapy compared with placebo plus chemotherapy in patients with inoperable recurrent triple-negative breast cancer (TNBC).

Phase

1.3 miles

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Evaluation of a Daily Brief Exercise Intervention on Resident Physician Personal Resiliency and Burnout

A cross-sectional evaluation of burnout, perceived stress, average sleep propensity, and social support and coping mechanisms will be assessed from four years of Vanderbilt University Medical Center (VUMC) Anesthesia residents. Burnout will be assessed using the Maslach Burnout Inventory (MBI-HSS). Participating interns, Anesthesia Residency Class 1 (CA-1), and Anesthesia Residency ...

Phase N/A

1.5 miles

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Neihulizumab (AbGn-168H) in Patients With Steroid-refractory Acute Graft-versus-host Disease

This study is a Phase I, single dose, dose-escalation study to study the pharmacokinetics, safety, signs of efficacy, receptor occupancy and pharmacodynamics biomarkers (REG3-alpha and ST2 of Neihulizumab in patients with steroid-refractory acute GvHD. Up to 24 patients will be recruited in 4-9 clinical centers in US.

Phase

1.5 miles

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The Impact of Branched-Chain Amino Acid Metabolism on Limb Dysfunction in PAD

Test the theory that abnormalities in the large blood vessels that deliver blood to your leg and the very small blood vessels in your leg's muscles (invisible to the eye) work together to worsen your leg function and walking.

Phase N/A

1.5 miles

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The purpose of this study is to determine the safety, tolerability, and efficacy of epacadostat when given in combination with nivolumab and ipilimumab, and in combination with nivolumab and lirilumab, in subjects with advanced or metastatic malignancies.

Phase N/A

1.5 miles

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