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Philadelphia, Pennsylvania Clinical Trials

A listing of Philadelphia, Pennsylvania clinical trials actively recruiting patient volunteers.

RESULTS

Found (25) clinical trials

Validating the MATADOC Against Best Practice Standard External Reference Standard

Adult patients with prolonged disorders of consciousness (PDOC), but who have not been diagnosed as Minimally Conscious or Vegetative State, will be recruited. All participants will be assessed using the Music Therapy Assessment Tool for Awareness in Disorders of Consciousness (MATADOC) standardized protocol. Assessment intervention will take place in four ...

Phase N/A

2.13 miles

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Parent-Level Predictors of Early Language Interaction Quality and Training Outcomes

Early language intervention is critical to improving the academic, social, vocational, and health outcomes of at-risk children under five. This at-risk group includes approximately 1.7 million children with primary developmental language disorder (DLD), 350,000 children with autism spectrum disorder (ASD) and millions in adverse early environments (e.g., 5 million children ...

Phase N/A

2.21 miles

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Ipilimumab and Nivolumab With Immunoembolization in Treating Participants With Metastatic Uveal Melanoma in the Liver

PRIMARY OBJECTIVES: I. Determine the clinical benefit of treatment with immunoembolization (IEMBO) in combination with ipilimumab and nivolumab. SECONDARY OBJECTIVES: I. Determine all treatment and immune related toxicities. II. Determine progression free survival. III. Determine overall survival.

Phase

4.27 miles

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Comparative Analysis of Sutures for Fascial Closure in Spinal Surgery

Effective and secure suture is integral in spinal surgery, creating a strong barrier for tissue repair and a seal which prevents infection of the surgical site. The goal of any suture is to close the wound while minimizing risks of complications such as wound dehiscence and surgical site infection . ...

Phase N/A

4.27 miles

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Palbociclib and Dexamethasone in Treating Participants With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

PRIMARY OBJECTIVES: I. To determine the dose and schedule of the combination of palbociclib and dexamethasone in patients with relapsed or refractory adult B-cell acute lymphoblastic leukemia (ALL). ii. To determine the safety and tolerability of the combination of palbociclib and dexamethasone in patients with relapsed or refractory adult B-cell ...

Phase

4.27 miles

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Temozolomide Radiation Therapy and Tumor Treating Fields Therapy in Treating Participants With Glioblastoma

PRIMARY OBJECTIVES: I. To evaluate the safety and toxicity of combination chemoradiotherapy with NovoTTF-200A device (Optune) treatment in newly diagnosed glioblastoma. SECONDARY OBJECTIVES: I. To determine the median progression-free survival of patients with newly diagnosed glioblastoma treated with radiotherapy with concurrent and adjuvant temozolomide plus Optune. II. To evaluate the ...

Phase N/A

4.27 miles

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Transcorneal Electrical Stimulation (TES) for the Treatment of Amblyopia

Amblyopia is defined as a decrease in visual acuity in one eye, despite the correction of any refractive error with glasses and in the absence of any ophthalmoscopically visible lesion of the retina, especially of the macular region. Amblyopia is associated with histologic and electrophysiologic abnormalities in the visual pathways. ...

Phase N/A

4.27 miles

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Molecular Monitoring With Circulating Tumor DNA and Nivolumab Maintenance

Primary Objective: To determine if nivolumab administration, as a maintenance strategy in DLBCL patients with high risk of relapse, can convert positive ctDNA to negative ctDNA and/or result in relapse free survival (RFS-ctDNA) of 9 months or longer after positive ctDNA was documented. Secondary Objectives: To evaluate safety of nivolumab ...

Phase N/A

4.43 miles

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Impact of Ribociclib on Head and Neck Squamous Cell Cancer

A window of opportunity study which would allow brief treatment of HPV negative SCCHN with a CDK4/6 inhibitor, in the pre-operative setting, with biomarker analyses of pre and post treatment tissue. Given that the standard treatment for this population is surgical resection, this would not impact or alter standard therapy ...

Phase N/A

4.43 miles

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An Investigational Immuno-Therapy Study to Determine the Safety and Effectiveness of Nivolumab and Daratumumab in Patients With Multiple Myeloma

NOTE: Currently, this study is only open to nivolumab+daratumumab vs daratumumab monotherapy in multiple myeloma patients.

Phase

4.43 miles

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