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Silver Spring, Maryland Clinical Trials

A listing of Silver Spring, Maryland clinical trials actively recruiting patient volunteers.

RESULTS

Found (11) clinical trials

Effects of an ER Beta Agonist (Lilly Compound LY500307) on Estradiol-Withdrawal-Induced Mood Symptoms in Women With Past Perimenopausal Depression

OBJECTIVE During the perimenopause, the incidence of depression increases 1-5 and predicts increased all-cause and cardiovascular mortality 6. A role of estradiol withdrawal in the onset of mood disorders in some perimenopausal women has been suggested indirectly by estradiol s antidepressant efficacy and safety in perimenopausal depression 7;8. Moreover, observational ...

Phase N/A

5.27 miles

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Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase 2 3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease

Polymerization of deoxy-sickle-hemoglobin (deoxy-HbS), the root cause of sickle cell disease (SCD) is influenced by a few factors, a key factor is 2,3-diphosphoglycerate (2,3-DPG) concentration in the red blood cells. 2,3-DPG is an allosteric effector on hemoglobin oxygen binding with a greater binding affinity to deoxygenated hemoglobin than to oxygenated ...

Phase N/A

5.27 miles

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Follow-Up Evaluation for Gene-Therapy-Related Delayed Adverse Events After Participation in Pediatric Oncology Branch Clinical Trials

Background Study subjects exposed to gene therapy interventions may be at risk for delayed or long term adverse consequences. The U.S. Food and Drug Administration (FDA) has issued Guidance for Industry: Gene Therapy Clinical Trials Observing Participants for Delayed Adverse Events, which outlines a framework to assess the risk of ...

Phase N/A

5.27 miles

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CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic Severe Calcific Aortic Stenosis Requiring Aortic Valve Replacement

A prospective, single-arm, controlled, multicenter study. Additional subjects may be enrolled in a bicuspid registry.

Phase N/A

6.11 miles

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Low-Fat Vegan Diet Versus a Mediterranean Diet on Body Weight

In a 36-week cross-over trial, overweight adults will consume a low-fat vegan diet and a Mediterranean diet in two separate 16-week phases. Changes in body weight will be the primary dependent variable. In addition, plasma lipid concentrations, insulin sensitivity, and postprandial metabolism will also be assessed and changes over time ...

Phase N/A

7.0 miles

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Preoperative Palbociclib in Patients With DCIS of the Breast That Are Candidates for Surgery

This is a feasibility study which will evaluate the effects of pre-operative treatment of DCIS of the breast with palbociclib. Patients with biopsy-proven DCIS are eligible for the study. There will be 2 independent and unrelated study groups of 12 patients each, for a total of 24 patients Group A, ...

Phase

8.07 miles

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The Genetic Education for Men Trial: Web-Based Education vs. Standard Care

Aim 1: Develop a web-based intervention to increase genetic counseling/testing uptake in men at high risk for carrying a BRCA mutation. Aim 2: Evaluate the impact of the web-based intervention (WI) vs. usual care (UC) Aim 3: Examine the behavioral and psychosocial impact of BRCA testing in men from BRCA ...

Phase N/A

8.07 miles

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Efficacy And Safety Evaluation of Glepaglutide in Treatment of SBS

A Phase 3, international, multicenter, randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of glepaglutide subcutaneous (SC) injections in patients with short bowel syndrome (SBS).

Phase

8.07 miles

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DC Longitudinal Study on Aging and Specimen Bank

These studies will examine the feasibility of using various biochemical assays in blood, and/or cerebrospinal fluid, genetic testing, cognitive status assessments, and lifestyle questionnaires to aid in the ante-mortem diagnosis of Alzheimer's and other neurodegenerative diseases. Subjects have 2 options for participation. They may solely participate in the main study ...

Phase N/A

8.7 miles

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A Study of A-101 Topical Solution for the Treatment of Common Warts

A Phase 3 Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of A-101 Topical Solution Applied Twice a Week in Subjects with Common Warts

Phase

9.8 miles

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