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Wythenshawe, United Kingdom Clinical Trials

A listing of Wythenshawe, United Kingdom clinical trials actively recruiting patients volunteers.

RESULTS

Found (417) clinical trials

Treatment of Patients With Diffuse Large B Cell Lymphoma Who Are Not Suitable for Anthracycline Containing Chemotherapy

The incidence of DLBCL is increasing and with an expanding elderly population, the incidence will continue to rise. Given that about 40% of cases of DLBCL occur in patients aged over 70 and the number of co-mobilities increases with age, research to investigate the optimal treatment of DLBCL in this ...

Phase

0.0 miles

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Rapid Assessment of Potential Ischaemic Heart Disease With CTCA

DESIGN: Open parallel group randomised controlled trial of early computed tomography coronary angiography (CTCA) in patients presenting with suspected/confirmed acute coronary syndrome (ACS) to Emergency Departments (ED) and Medical Assessment Units. SETTING: 30 EDs, radiology, cardiology and acute medical services in tertiary/district general National Health Service (NHS) hospitals. TARGET POPULATION ...

Phase N/A

0.0 miles

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A Study of the Effect of Linaclotide on Abdominal Girth in Participants With IBS-C

The objective of this trial is to determine the effect of linaclotide on abdominal girth in irritable bowel syndrome with constipation (IBS-C) participants with the baseline symptoms of abdominal bloating and an increased abdominal girth.

Phase

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A Study Looking at the Safety Tolerability and Efficacy of the Combination of the Study Drugs GLPG2451 and GLPG2222 With or Without GLPG2737 in Patients With Cystic Fibrosis.

This is a Phase Ib, multi-center, open-label, nonrandomized multiple cohorts study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple doses of a combination treatment of GLPG2451 and GLPG2222, with and without GLPG2737, in adult subjects with Cystic Fibrosis.

Phase

0.0 miles

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Repeat Doses of BAY 1902607 in Healthy Males and Proof of Concept in Chronic Cough Patients

The primary objectives of this study are to: Investigate the safety and tolerability of ascending repeated oral doses of BAY1902607 in healthy subjects (Part 1). Investigate the effect of BAY1902607 on the pharmacokinetics (PK) of a sub-therapeutic 1 mg dose of midazolam (Part 1). Investigate the safety, tolerability and efficacy ...

Phase

0.89 miles

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Pharmacodynamics Pharmacokinetics and Safety of Two Doses of CHF6001 DPI in Subjects With Moderate Severe COPD

The purpose of this study is to obtain information on the effects of two doses of CHF6001 on sputum and blood biomarkers of inflammation in subjects with symptomatic COPD with moderate, severe airflow limitation and with chronic bronchitis. The efficacy of the treatment will also be measured using forced oscillometry ...

Phase

1.12 miles

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Effect of Mepolizumab in Severe Bilateral Nasal Polyps

Nasal polyps (NP) has long been known as chronic inflammatory disease of the nasal mucosa. This disease is characterized by the presence of polyps in the upper nasal cavity, originating from within the ostiomeatal complex. The presence of polyps can cause long-term symptoms such as prominent nasal obstruction, post-nasal drip, ...

Phase

1.12 miles

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Safety and Tolerability of MEDI3506 in Healthy Subjects and in Subjects With Chronic Obstructive Pulmonary Disease

This is a Phase 1, randomised, blinded, placebo controlled, study designed to evaluate the safety, tolerability, pharmacokinetics, and immunogenicity response to single and multiple doses of MEDI3506 administered by either SC or IV routes. Part I: Single Ascending Doses in Healthy Subjects with a History of Mild Atopy Part II: ...

Phase

1.12 miles

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K1-70 - A Study in Subjects With Graves' Disease

Graves' disease is one of the most common overt autoimmune disorders. Patients with Graves' disease have thyroid over activity and hyperthyroidism. Symptoms of hyperthyroidism include goitre, fatigue, heat intolerance, sweating, weight loss despite good appetite, shakiness, inappropriate anxiety, palpitations of the heart, shortness of breath, tetchiness and agitation, poor sleep, ...

Phase

1.12 miles

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Phase 2a AMP Challenge Dose Escalation Study to Assess the Dose Response for Topical Efficacy and Systemic Activity in Asthmatic Subjects

This is a randomized, placebo-controlled, 2-period crossover, escalating repeat dose study, aiming to investigate whether higher potency of different inhaled corticosteroid confers an improvement in the topical efficacy to systemic activity ratio in asthmatic subjects. It will compare the dose response for topical efficacy via airway responsiveness (to adenosine-5'-monophosphate [AMP] ...

Phase

1.12 miles

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