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Ruddington, United Kingdom Clinical Trials

A listing of Ruddington, United Kingdom clinical trials actively recruiting patients volunteers.

RESULTS

Found (232) clinical trials

A Study of the Safety Tolerability Pharmacokinetics and Pharmacodynamic Effects of Single and Multiple Ascending Doses of GDC-0334 and the Effect of Food on the Pharmacokinetics of GDC-0334 in Healthy Adult Participants

This is a randomized, double-blind, placebo-controlled, single-center, three-part study designed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamic effects of single and multiple ascending doses of GDC-0334 and the effect of food on the pharmacokinetics of GDC-0334 in healthy adult participants.

Phase

0.92 miles

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A Study to Compare the Pharmacokinetics of GSK2982772 Following Administration of Different Modified Release (MR) Formulations in Capsule Relative to an Immediate Release (IR) Tablet Formulation and to Investigate the Pharmacokinetics of a Selected MR Formulation in Capsule Following Repeat Doses

This study will evaluate the pharmacokinetics of GSK2982772 following administration of modified release formulations in a capsule relative to an immediate release reference tablet formulation and the pharmacokinetics of escalating repeat doses of a selected modified release prototype. The study is divided into two parts: Part A will be a ...

Phase

0.92 miles

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A Study to Investigate the Effect of Formulation Food and Rabeprazole on the Pharmacokinetics (PK) of GDC-0853 in Healthy Participants

The purpose of this study is to evaluate the PK of GDC-0853 following changes to formulation and in the presence or absence of food, the proton pump inhibitor (rabeprazole), or both. This will be a 3-part open-label randomized study conducted in healthy adult participants. Approximately 63 subjects will be enrolled ...

Phase

0.92 miles

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Study to Compare the Pharmacokinetics and Pharmacodynamics of 6 mg RGB-02 to 6 mg Neulasta

Single-centre, double-blind, randomised, two-period, two-way crossover study to investigate the pharmacokinetics and pharmacodynamics of RGB-02 as compared to Neulasta® administered as a single subcutaneous injection in healthy adult subjects.

Phase

0.92 miles

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Impact of Changing the Dosing Regimen on the PK Profile of ODM-203

This study will be a single dose part randomised cross over study with up to 6 study periods. ODM-203 may be dosed using a variety of different conditions with respect to food depending on emerging data. The impact of changing the presentation of ODM-203 may also be assessed to determine ...

Phase

0.92 miles

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First-in-Human Single and Multiple Dose of EB8018

Crohn's Disease is a chronic inflammatory disease of the gastrointestinal tract. Emerging evidence suggests that the microbiome plays an important role in triggering an abnormal mucosal immune response in patients with Crohn's Disease. Independent studies have demonstrated an imbalance of the microbiome with a significant increase of E coli with ...

Phase

0.92 miles

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A Phase 1 Bioavailability Study of Arbaclofen Placarbil Modified Release Formulations in Healthy Volunteers

For Parts 1, 2 and 3, participants will attend the clinical unit for a screening visit up to 28 days before dosing. For each treatment period, eligible subjects will be admitted to the clinical unit on the evening before dosing (Day -1). Participants will receive each regimen in the morning ...

Phase

0.92 miles

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First in Human Single Ascending Dose Study of MOR107

MOR107 is an angiotensin 2 receptor (AT2R) agonist with the potential to treat a wide range of diseases through activation of the protective arm of the renin-angiotensin system. In this study MOR107 will be administered to humans for the first time. The study will enroll healthy male subjects and is ...

Phase

0.92 miles

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A 4-Part Study In Healthy Volunteers To Evaluate Safety And Tolerability Of The Test Medicine MEDI7219 and to See How it is Taken up by the Body When Given as Single and Multiple Doses

MEDI7219 is being developed for the potential treatment of type 2 diabetes. The study is a first in human, single and multiple ascending dose study that will try to identify the safety, tolerability and pharmacokinetics (how the drug moves through the body) of MEDI7219. The study will also look at ...

Phase

0.92 miles

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First-in-human Study in Healthy Subjects

This is a 5-part, single-center study of single and multiple ascending doses of CORT118335 in healthy subjects. Parts I and 4 of the study are double-blind, randomized, placebo-controlled assessments of single-ascending doses (SAD) of CORT118335. Subjects will be enrolled sequentially into 1 of up 8 cohorts (Part 1, Cohorts A ...

Phase

0.92 miles

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