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Northwick Park, United Kingdom Clinical Trials

A listing of Northwick Park, United Kingdom clinical trials actively recruiting patients volunteers.

RESULTS

Found (82) clinical trials

Safety and Tolerability of MEDI3506 in Healthy Subjects and in Subjects With Chronic Obstructive Pulmonary Disease

This is a Phase 1, randomised, blinded, placebo controlled, study designed to evaluate the safety, tolerability, pharmacokinetics, and immunogenicity response to single and multiple doses of MEDI3506 administered by either SC or IV routes. Part I: Single Ascending Doses in Healthy Subjects with a History of Mild Atopy Part II: ...

Phase

0.13 miles

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Bioequivalence Study of Combination Tablets of Saxagliptin / Dapagliflozin / Metformin XR (Extended-release) and Dapagliflozin / Metformin XR Relative to Individual Components in Healthy Subjects

This study will be an open-label, randomized, 3-period, 3-treatment, single-dose crossover study in healthy subjects (males and females), performed at a single study center, conducted in 3 cohorts. A total of 126 healthy male or female subjects (3 cohorts of 42 subjects each [each cohort consisting of 3 treatments]) will ...

Phase

0.13 miles

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A Phase I Study to Assess the Safety Tolerability Pharmacokinetics Pharmacodynamics and Food Effect of AZD9898

This study will be a Phase I, randomized, placebo-controlled study in healthy subjects and asthma patients, performed at 2 study centers. The study will consist of 3 parts (Part 1 [SAD in healthy subjects]; Part 2 [SAD in asthma patients]; Part 3 [MAD in healthy subjects under fasted conditions, with ...

Phase

0.13 miles

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First Time in Human (FTIH) Study to Evaluate Safety Tolerability Immunogenicity Pharmacokinetics (PK) and Pharmacodynamics (PD) of GSK3511294 Administered Subcutaneously (SC) in Subjects With Mild to Moderate Asthma

GSK3511294 is a humanized monoclonal antibody antagonist of Interleukin (IL)-5 which is known to block binding of IL-5 to the IL-5 receptor complex, causing a reduction in the circulating population of eosinophils. This is a single ascending dose FTIH study to investigate safety, tolerability, immunogenicity, pharmacokinetics (PK) and pharmacodynamics (PD) ...

Phase

0.13 miles

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A Pharmacokinetic Study of the Effect of Itraconazole Exposure to Orvepitant in Healthy Volunteers

A Phase 1 study to assess the effect of itraconazole, a strong inhibitor of CYP3A and P-glycoprotein, on the pharmacokinetics (PK) of orvepitant in healthy male volunteers. Subjects will receive two single doses of 20mg orvepitant, once alone and once in combination with repeat doses of itraconazole. All subjects will ...

Phase

0.13 miles

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A First Time in Human Study of PIN201104 in Healthy Volunteers and Patients With Asthma

The purpose of this study is to assess the safety, tolerability and pharmacokinetics of different single and repeat doses of PIN201104 in healthy volunteers and in patients with asthma.

Phase

1.03 miles

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A Study to Assess How Much Drug Reaches the Blood When Given From Symbicort pMDI With Spacer Compared to That of Symbicort pMDI Without Spacer in Healthy Volunteers

Study Design: This study will be a randomised, open-label, single-dose, crossover study in healthy subjects (males and females), performed at a single study centre. The study will comprise: - A screening period of maximum 28 days; - Four treatment periods during which subjects will be resident from the afternoon before ...

Phase

1.03 miles

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Single Ascending Dose Study of Lu AF76432 in Healthy Young Men

The purpose of this study is to investigate safety, tolerability and pharmacokinetics of the drug Lu AF76432 given as single oral ascending doses to healthy young men

Phase

1.03 miles

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A Study to Assess the Safety Tolerability Pharmacokinetics Immunogenicity and Pharmacodynamics of JNJ-64179375 in Healthy Japanese Participants

The primary purpose of this study is to assess the safety and tolerability of JNJ-64179375 in Part 1 and 2.

Phase

3.59 miles

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Assessment of Pharmacokinetics (PK) and Safety of M834 and Orencia in Healthy Subjects

The purpose of this study is assess the pharmacokinetics and safety of M834 and Orencia ® following administration of a single-dose in healthy volunteers.

Phase

3.59 miles

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