Search Medical Condition
Please enter condition
Please choose location from dropdown

Addenbrooke's Hospital, Cambridge, United Kingdom Clinical Trials

A listing of Addenbrooke's Hospital, Cambridge, United Kingdom clinical trials actively recruiting patients volunteers.

RESULTS

Found (217) clinical trials

Combination Chemotherapy With or Without Filgrastim Before Surgery High-Dose Chemotherapy and Radiation Therapy Followed by Isotretinoin With or Without Monoclonal Antibody in Treating Patients With Neuroblastoma

OBJECTIVES: - Compare the efficacy of myeloablative therapy with busulfan and melphalan vs carboplatin, etoposide, and melphalan, in terms of 3- and 5-year event-free survival (EFS), progression-free survival (PFS), and overall survival (OS), in patients with high-risk neuroblastoma. - Compare the 3-year EFS in these patients treated with isotretinoin with ...

Phase

2.3 miles

Learn More »

Functional Genomic Influences on Disease Progression and Outcome in Sepsis

The investigators plan to recruit 2,000 cases of community acquired pneumonia (CAP) and 2,000 cases of faecal peritonitis (FP) from 30 UK ICUs and HDUs (members of the UK Critical Care Genomics group UKCCG). The large number of patients is required to satisfy the power calculations based upon the predicted ...

Phase N/A

2.3 miles

Learn More »

Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle

OBJECTIVES: - To assess whether a reduced computed tomography (CT) schedule or magnetic resonance imaging (MRI) could be used as safe and effective alternatives to standard CT-based surveillance in the management of patients with stage I seminoma of the testis. OUTLINE: This is a multicenter study. Patients are randomized to ...

Phase

2.3 miles

Learn More »

Study of DNA Mutations in Predicting the Effect of External-Beam Radiation Therapy in Patients With Early Breast Cancer Localized Prostate Cancer or Gynecological Cancer

OBJECTIVES: Primary - To test the hypothesis that an association between common genetic variations, reported by single nucleotide polymorphisms (SNP) in relevant candidate genes, is associated with individual patient variability in normal tissue radiation response and toxicity. Secondary - To compare different clinical scoring systems for late normal tissue effects, ...

Phase N/A

2.3 miles

Learn More »

Trastuzumab in Treating Women With HER2-Positive Early Breast Cancer

OBJECTIVES: Primary - Determine disease-free survival of women with HER2-positive early breast cancer treated with neoadjuvant or adjuvant trastuzumab (Herceptin®) for 6 months versus 12 months. Secondary - Determine the overall survival of patients treated with these regimens. - Determine the expected incremental cost effectiveness (cost per quality adjusted life ...

Phase

2.3 miles

Learn More »

Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma

OBJECTIVES: - Improve the outcome in pediatric patients with low-risk rhabdomyosarcoma (RMS) treated with vincristine and dactinomycin alone. - Evaluate whether the outcome for older patients with standard-risk RMS with favorable features may be improved/maintained by administering a treatment with limited intensity. - Evaluate whether chemotherapy intensity for patients with ...

Phase

2.3 miles

Learn More »

Early Metabolic Changes With Thiazide or Beta Blocker Therapy for Essential Hypertension

We will be comparing the two most commonly used drugs to treat hypertension, atenolol and bendrofluazide, in patients for whom the drugs (and the doses to be used) are licenced. We propose an initial open label pilot study of 10-12 patients to confirm final doses to be tested, the duration ...

Phase N/A

2.3 miles

Learn More »

Irinotecan With or Without Panitumumab or Cyclosporine in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did Not Respond to Fluorouracil

OBJECTIVES: Primary - Compare the efficacy and toxicity of single-agent irinotecan hydrochloride (Ir) vs Ir with cyclosporine (IrC) in patients with fluorouracil-resistant advanced colorectal cancer. - Compare the efficacy of single-agent Ir vs Ir with panitumumab (IrP) in these patients. Secondary - Correlate the toxicity of Ir and/or IrC with ...

Phase

2.3 miles

Learn More »

Intensity-Modulated Radiation Therapy in Treating Patients With Localized Prostate Cancer

OBJECTIVES: - Determine the safety and efficacy of conventional vs hypofractionated high-dose intensity-modulated radiotherapy in patients with localized prostate cancer. - Determine the side effects of these regimens in these patients. - Determine whether hypofractionated radiotherapy schedules will improve the therapeutic ratio by either improving tumor control or reducing normal ...

Phase

2.3 miles

Learn More »

Double Blind Crossover Comparison of Diuretics in the Young

Studies suggest that patients with low renin hypertension respond better to diuretics than other hypertensive drug groups. The aim of the study is to rotate patients through the four main diuretic groups and see if it is possible to identify the most effective diuretic for this group, as measured by ...

Phase N/A

2.3 miles

Learn More »