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Acton, United Kingdom Clinical Trials

A listing of Acton, United Kingdom clinical trials actively recruiting patients volunteers.

RESULTS

Found (13) clinical trials

A First-In-Human Study of Orally Administered JNJ-64417184 to Evaluate the Safety Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses and the Antiviral Activity of Multiple Doses in a Respiratory Syncytial Virus (RSV) Challenge Study in Healthy Participants

The purpose of the study is to evaluate the safety and tolerability of single and multiple oral doses of JNJ-64417184 administered to healthy participants and the antiviral effect of multiple oral doses of JNJ-64417184 compared to placebo in participants infected through inoculation with respiratory syncytial virus (RSV)-A Memphis 37b (Part ...

Phase

1.5 miles

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Investigating the Physiological Effects of Weight Loss on Male Fertility

Participants will receive dietary supplements or NHS advice on healthy eating to achieve weight loss.

Phase N/A

1.76 miles

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A Study Evaluating the Efficacy and Safety of AG-348 in Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD)

Study AG348-C-007 is a multicenter study designed to evaluate the efficacy and safety of treatment with AG-348 in approximately 15-20 adult participants with pyruvate kinase deficiency (PKD), who are regularly receiving blood transfusions. The study is comprised of two parts. During the Part 1 Dose Optimization Period of the study, ...

Phase

1.82 miles

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TAK-954 in Critically Ill Participants With Enteral Feeding Intolerance (EFI)

The drug being tested in this study is called TAK-954. The study will assess the treatment effect of intravenous TAK-954 in improving average daily protein adequacy received through enteral nutrition in critically ill participants with EFI. The study will enroll approximately 200 participants. Participants will be randomly assigned (by chance, ...

Phase

5.05 miles

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Research Into Antipsychotic Discontinuation and Reduction

Who can participate? Adults who have been diagnosed with schizophrenia, psychosis or a similar condition and are taking antipsychotic medication. What does the study involve? Once a person agrees to take part, they are randomly selected to receive either the 'antipsychotic reduction programme' or 'maintenance treatment'. The 'antipsychotic reduction programme' ...

Phase

6.0 miles

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Non-Interventional Study on the Tolerability and Efficacy of IVIG

A Non-Interventional Study on the Tolerability and Efficacy of Octagam 5% or 10% or panzyga. Patients with any indication (replacement and immonomodulation) as prescribed by the treating physician. Marketed Octagam 5% or 10% or panzyga will be used according to the investigator prescription; intravenous (iv) administration.The primary objective is to ...

Phase N/A

6.31 miles

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Domiciliary Transcutaneous Electrical Stimulation in Obstructive Sleep Apnoea

Obstructive sleep apnoea is highly prevalent, with the obesity epidemic increasing the problem. The best treatment for uncomplicated and moderate-severe OSA remains CPAP therapy. However, long-term adherence to treatment with CPAP is poor and there are few alternatives. Electrical stimulation of the dilator muscles of the upper airway has been ...

Phase N/A

6.7 miles

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Study to Evaluate the QT / QTc Interval Prolongation Potential of Vericiguat

The objective of this study is to evaluate the effect of multiple doses of vericiguat on the QTc interval in patients with stable CAD (coronary artery disease).

Phase

7.06 miles

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Evaluation of CTCA in Assessing Plaque Pathology and Physiology

Cumulative evidence has demonstrated that plaque characteristics and vessel physiology are able to detect vulnerable plaques and identify high-risk individuals that are likely to suffer a cardiovascular event. The in vivo assessment of plaque morphology was traditionally performed using intravascular imaging techniques; however these modalities have significant limitations as: 1) ...

Phase N/A

7.49 miles

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The Role of Ixazomib in Autologous Stem Cell Transplant in Relapsed Myeloma - Myeloma XII (ACCoRd)

Study design: Randomised, controlled, multi-centre, open-label, phase III trial (with a single intervention registration phase). Primary Objectives The primary objectives of this study are to determine: The impact on Depth of Response (DoR: less than VGPR versus VGPR or better) when salvage ASCT conditioning is augmented by the addition of ...

Phase

7.59 miles

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