Search Medical Condition
Please enter condition
Please choose location from dropdown
 

Acton, United Kingdom Clinical Trials

A listing of Acton, United Kingdom clinical trials actively recruiting patients volunteers.

RESULTS

Found (1114) clinical trials

Adjunctive Ganglionated Plexus Ablation in Redo-Pulmonary Vein Isolation

Patients with ongoing paroxysmal arrhythmias after pulmonary vein isolation (PVI) for paroxysmal and persistent atrial fibrillation (AF) get incrementally less benefit with redo-PVI. This implies non-pulmonary vein (PV) triggers, which are more challenging to locate. The autonomic nervous system is implicated in the multifactorial pathogenesis of AF but few studies ...

Phase

0.48 miles

Learn More »

Assessment of Pharmacokinetics (PK) and Safety of M834 and Orencia in Healthy Subjects

The purpose of this study is assess the pharmacokinetics and safety of M834 and Orencia ® following administration of a single-dose in healthy volunteers.

Phase

1.5 miles

Learn More »

First in Man Clinical Trial of Emodepside (BAY 44-4400)

This study will investigate the safety, tolerability, and pharmacokinetics of single ascending doses of emodepside (BAY 44-4400) in healthy male volunteers. This study will also conduct an exploratory investigation of the relative bioavailability of emodepside administered as tablets.

Phase

1.5 miles

Learn More »

Long-term Safety Follow-up of Participants Exposed to the Candidate Ebola Vaccines Ad26.ZEBOV and/or MVA-BN-Filo

This is a multi-country, prospective, long-term clinical safety study for collection of serious adverse events and pregnancy outcomes following administration of Ad26.ZEBOV and/or MVA-BN-Filo vaccines among participants who were enrolled in Phase 1, 2 or 3 clinical studies. The safety data will be collected in 3 cohorts; Cohort 1- adult ...

Phase

1.5 miles

Learn More »

Multiple Treatment Session Study to Assess GSK2398852 Administered Following and Along With GSK2315698

The study is intended to evaluate whether monthly repeated courses of administration of GSK2315698 followed by GSK2398852 is associated with a reduction in cardiac amyloid load in patients with cardiac amyloidosis, monitored by cardiac magnetic resonance imaging (CMR) and echocardiography (ECHO), and whether this is associated with an improvement in ...

Phase

1.5 miles

Learn More »

Safety Tolerability & Pharmacokinetics of LEVI-04 in Healthy Volunteers and Patients With Osteoarthritis Knee Pain

There will be 8 cohorts of 7 subjects each. Cohorts 1-3 will be composed of healthy volunteers. Cohorts 4-8 will be composed of osteoarthritis patients. Cohort 4 will be a bridging cohort; osteoarthritis patients in Cohort 4 will receive the same dose as the healthy volunteers in Cohort 3, if ...

Phase

1.5 miles

Learn More »

A Two Part Study to Assess Safety PK PD and Food Effect of Oral HTL0016878

This is a first in human single and multiple ascending dose study with the objective to evaluate safety, tolerability, PK, PD, and food effect of HTL0016878 in healthy younger and elderly subjects. Part 1 will assess single doses of HTL0016878 and Part 2 will assess multiple doses of HTL0016878. Part ...

Phase

1.5 miles

Learn More »

Safety Tolerability and PK of Multiple-ascending Doses of Emodepside

There is an urgent need for a macrofilaricidal drug, killing or sterilizing permanently O. volvulus adult worms, which could be used in individual case management and, after appropriate testing, as an alternative drug to ivermectin in MDA programs. Emodepside is a promising candidate to kill the adult and sexually mature ...

Phase

1.5 miles

Learn More »

First Time in Human (FTIH) Study to Evaluate Safety Tolerability Immunogenicity Pharmacokinetics (PK) and Pharmacodynamics (PD) of GSK3511294 Administered Subcutaneously (SC) in Subjects With Mild to Moderate Asthma

GSK3511294 is a humanized monoclonal antibody antagonist of Interleukin (IL)-5 which is known to block binding of IL-5 to the IL-5 receptor complex, causing a reduction in the circulating population of eosinophils. This is a single ascending dose FTIH study to investigate safety, tolerability, immunogenicity, pharmacokinetics (PK) and pharmacodynamics (PD) ...

Phase

1.5 miles

Learn More »

A Study to Investigate the Antidepressant Mechanism-of-action of JNJ-42847922 in Participants With Major Depressive Disorder

The purpose of this study is to explore if the magnitude of treatment effect (JNJ-42847922; placebo) on symptoms of depression (as measured by Hamilton rating scale for depression-17 [HDRS17], Sleep item-adjusted HDRS17, Anxiety/somatization factor score and the 6-item subscale from HDRS17 [HAM-D6]) differs across different levels of hyper-arousal status (characterized ...

Phase

1.5 miles

Learn More »