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AZ Maastricht, Netherlands Clinical Trials

A listing of AZ Maastricht, Netherlands clinical trials actively recruiting patients volunteers.

RESULTS

Found (283) clinical trials

Neurotoxic Adverse Effects of Morphine and Oxycodone for Pain in Terminal Patients With Diminished Renal Function

INTRODUCTION AND RATIONALE: Significant pain is a common condition in dying patients. Continuous subcutaneous infusion (CSCI) of opioids is the cornerstone in treatment of pain in this last phase of life. Although morphine is the most frequent used opioid in this respect, its main metabolites start to accumulate when renal ...

Phase

0.26 miles

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Study of Dexamethasone Plus IXAZOMIB (MLN9708) or Physicians Choice of Treatment in Relapsed or Refractory Systemic Light Chain (AL) Amyloidosis

The drug being tested in this study is called IXAZOMIB. IXAZOMIB was being tested to treat people who have relapsed or Refractory Systemic Light Chain (AL) Amyloidosis. The study will enroll approximately 248 patients. Participants will be randomly assigned (by chance, like flipping a coin) to one of the two ...

Phase

1.64 miles

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Neural Correlates of Repeated tDCS

Healthy ageing and pathological ageing in the context of a neurodegenerative disease are both associated with changes in brain network integrity. Episodic memory is especially affected in Alzheimer's disease, but is also decreased in healthy ageing. Consequently, the memory-relevant brain networks are especially altered. Transcranial direct current stimulation (tDCS) has ...

Phase N/A

1.75 miles

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Ribavirin Its Dosing Regime

The standard treatment of patients with chronic hepatitis C infection (HCV) is treatment with ribavirin. Actually, the compliance (2x daily) seems to be a problem. To increase patients' compliance, it is investigated if the total dose of ribavirin can be taken once daily. The pharmacokinetics of ribavirin at different dosage ...

Phase

1.88 miles

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Development of an Acceleration Based Fall Risk Detector

A first step to field measurement with target group is the measurement of elderly with a certain fall risk in a simple field condition like a nursing home. First fall risk is assessed in elderly using the Tinetti scale (score between 19-24) which is the gold standard for fall risk ...

Phase N/A

1.88 miles

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Algae and Cholesterol Absorption

Objectives Secondary objectives are to investigate the effects of wakame and spirulina consumption on fasting markers for lipid metabolism, glucose metabolism and blood pressure. Study design: This study is a double-blinded, randomized, placebo-controlled, crossover intervention trial consisting of three intervention periods of 17 days each, separated by a minimum washout ...

Phase N/A

1.88 miles

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NAD Supplementation Study

This research project aims to determine whether supplementing with a mixture of the NAD+-precursors NA, NAM, and tryptophan can stimulate skeletal muscle mitochondrial function in physically compromised, elderly humans. Outcomes are related to mitochondrial function, energy metabolism, and physical function will be investigated.

Phase N/A

1.88 miles

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Carnitine Supplementation in Type 2 Diabetic Patients

Rationale: Type 2 diabetic patients are characterized by a decreased metabolic flexibility: a reduced capability to switch from fat oxidation in the basal state to carbohydrate oxidation in the insulin-stimulated state. This metabolic inflexibility is an early hallmark in the development of diabetes. Recent evidence suggests that a low carnitine ...

Phase N/A

1.88 miles

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Rhodospirillum Rubrum and Cholesterol

Objectives Secondary objectives are to investigate the effects on other CVD risk parameters: total cholesterol, triacylglycerol, HDL-C, glucose and blood pressure. Safety will be monitored by measurements of markers for liver, kidney and heart function. Study design: The study is a 4-weeks randomized, double-blind placebo-controlled trial with a parallel design ...

Phase N/A

1.88 miles

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Assessment of Responsiveness to Treatment by Experience Sampling Method

The primary objective of this study is to assess the internal and external responsiveness of the ESM-PROM in examining changes in symptom scores between baseline and post-treatment. Secondary objectives are to identify differences in characteristics between responders and non-responders to linaclotide and to assess for side effects of linaclotide treatment, ...

Phase N/A

1.88 miles

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