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AZ Maastricht, Netherlands Clinical Trials

A listing of AZ Maastricht, Netherlands clinical trials actively recruiting patients volunteers.

RESULTS

Found (288) clinical trials

Neurotoxic Adverse Effects of Morphine and Oxycodone for Pain in Terminal Patients With Diminished Renal Function

INTRODUCTION AND RATIONALE: Significant pain is a common condition in dying patients. Continuous subcutaneous infusion (CSCI) of opioids is the cornerstone in treatment of pain in this last phase of life. Although morphine is the most frequent used opioid in this respect, its main metabolites start to accumulate when renal ...

Phase

0.26 miles

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Study of Dexamethasone Plus IXAZOMIB (MLN9708) or Physicians Choice of Treatment in Relapsed or Refractory Systemic Light Chain (AL) Amyloidosis

The drug being tested in this study is called IXAZOMIB. IXAZOMIB was being tested to treat people who have relapsed or Refractory Systemic Light Chain (AL) Amyloidosis. The study will enroll approximately 248 patients. Participants will be randomly assigned (by chance, like flipping a coin) to one of the two ...

Phase

1.64 miles

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Neural Correlates of Repeated tDCS

Healthy ageing and pathological ageing in the context of a neurodegenerative disease are both associated with changes in brain network integrity. Episodic memory is especially affected in Alzheimer's disease, but is also decreased in healthy ageing. Consequently, the memory-relevant brain networks are especially altered. Transcranial direct current stimulation (tDCS) has ...

Phase N/A

1.75 miles

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Experience Sampling Method for Symptom Assessment in Irritable Bowel Syndrome

Reliable patient reported outcome measures (PROM's) for symptom assessment in irritable bowel syndrome are essential in order to investigate natural disease course and potential treatment options aimed at symptom improvement, since biological markers are currently unavailable. Currently used symptom assessment methods, i.e. end-of-day or end-of-week questionnaires, have considerable limitations. The ...

Phase N/A

1.88 miles

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NWT03 and Arterial Stiffness

Rationale: Subjects with the metabolic syndrome have an increased risk of developing cardiovascular disease and a twofold risk of developing hypertension. A functional food ingredient with the ability to improve arterial stiffness, microcirculation and/or the ability to reduce blood pressure could potentially contribute to the delay or prevention of a ...

Phase

1.88 miles

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fMRI and Visceral Perception Upon Capsaicin Infusion

Brain imaging has shown abnormal brain activations in response to visceral stimulation in patients with the Irritable Bowel Syndrome (IBS). To investigate the possible role of the Nucleus of the Solitary Tract (NTS), the primary relay station in the brainstem for vagal afferents, its activation in IBS and functional dyspepsia ...

Phase N/A

1.88 miles

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Ribavirin Its Dosing Regime

The standard treatment of patients with chronic hepatitis C infection (HCV) is treatment with ribavirin. Actually, the compliance (2x daily) seems to be a problem. To increase patients' compliance, it is investigated if the total dose of ribavirin can be taken once daily. The pharmacokinetics of ribavirin at different dosage ...

Phase

1.88 miles

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Rhodospirillum Rubrum and Cholesterol

Objectives Secondary objectives are to investigate the effects on other CVD risk parameters: total cholesterol, triacylglycerol, HDL-C, glucose and blood pressure. Safety will be monitored by measurements of markers for liver, kidney and heart function. Study design: The study is a 4-weeks randomized, double-blind placebo-controlled trial with a parallel design ...

Phase N/A

1.88 miles

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High Intensity Interval Training and Skeletal Muscle Insulin Sensitivity

42 overweight-obese (BMI 25-35 kg/m2), sedentary females and males aged 45-65yr will be enrolled in this study. This study will be conducted in 2 randomized intervention groups; HIIT+ carbohydrate-rich beverage HIIT+ water. Both groups will train 3 times/week under supervision during 12 weeks (period 1) and remotely supervised during 40 ...

Phase N/A

1.88 miles

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Plant Sterols and Plant Stanols and Liver Inflammation

The objective is to assess the effect of consuming plant sterol or plant stanol esters (3 grams/day) for 12 months on biopsy proven liver inflammation in NAFLD patients. This study is a randomized, placebo-controlled, double blinded pilot study with a run-period of 2 weeks, an intervention period of 12 months ...

Phase N/A

1.88 miles

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