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Toronto, Canada Clinical Trials

A listing of Toronto, Canada clinical trials actively recruiting patients volunteers.

RESULTS

Found (963) clinical trials

Determining Disease Activity Biomarkers in Individuals With Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)

EGPA, also known as allergic granulomatosis angiitis, is a systemic vasculitis. EGPA is marked by three distinct symptoms: asthma; eosinophilia, evidenced by an excessive number of eosinophils in the blood and tissues; and vasculitis involving the skin, lungs, nerves, kidneys, and other organs. Nerve involvement may also occur in EGPA, ...

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Ocular Blood Flow in Early Glaucoma Patients Before and After Treatment With Dorzolamide

High intraocular pressure (IOP) is the major risk factor for glaucoma. Lowering intraocular pressure is still the only accepted form of treatment for glaucoma. Over the past decade, epidemiological and experimental evidence suggested that impaired ocular blood flow is an important risk factor with an important role in the pathogenesis ...

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Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis

The objective of this study is to identify genes that are specifically up or down regulated in chronic viral hepatitis and autoimmune liver disease and then to examine how these expression patterns relate (if at all) to clinical outcome. The expression pattern of thousands of genes should provide extremely powerful ...

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Early Diagnosis of Lung Cancer and Mesothelioma in Prior Asbestos Workers

Background and Purpose: Asbestos exposure may result in several different diseases to the lung and to the lining of the lung, the so-called pleura. Mostly they are benign, but there are two common malignant diseases in people with prior asbestos exposure, the so-called mesothelioma - which originates from the pleura ...

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The Results of Ahmed Valve Operations

Glaucoma drainage devices are usually placed in the superior quadrants. The superotemporal quadrant is usually the site of choice. However, when the upper fornix is scarred and especially when conjunctiva is two fibrotic to enable adequate coverage of tube with a scleral or other patch graft, some surgeons place the ...

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Augmented Wide Area Circumferential Catheter Ablation for Reduction of Atrial Fibrillation Recurrence

Clinical relevance: The problem of PV reconnection and recurrent AF after catheter ablation for paroxysmal AF is one of the important challenges faced by treating physicians. Rationale The understanding of the role contact force plays in adequate lesion formation during catheter ablation and the fact that this may reduce pulmonary ...

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Prevention of Alzheimer's Disease With CR Plus tDCS in Mild Cognitive Impairment and Depression (PACt-MD)

By the time Alzheimer's Dementia (AD) and related disorders (ADRD) are diagnosed the brain has sustained substantial insult that limits the efficacy of current treatments. Preventive interventions are urgently needed but prevention studies require large numbers of participants and long follow-up periods unless they can target a high-risk population. The ...

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Exercise in Genetic Cardiovascular Conditions

Yale is the central site for this multicenter study. Patients with HCM and LQTS will be recruited via high-volume HCM and LQTS sites, patient-groups, and websites. Information about exercise participation will be acquired via interview and online instruments at enrollment and every six months for three years. Quality of Life ...

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Database for Stroke in Infants and Children

OBJECTIVES: This is the first multi-center, multi-national study of children with stroke. It seeks to build a network of investigators and baseline disease data to enable childhood stroke clinical trials to be developed. STUDY POPULATION: Infants and children with ischemic stroke (arterial ischemic stroke and sinovenous thrombosis). DESIGN: This study ...

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Collection of Tissue Samples for Cancer Research

Background -Patients who are being evaluated and/or treated at the NIH Clinical Center or participating sites will be entered onto this tissue procurement protocol for collection of tissue specimens. Objectives To obtain samples for research purposes from tests performed for clinical & research indications on other research protocols. To obtain ...

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