Clinical Trial Details

NCT ID: NCT02876835
Date Last Changed: October 16, 2017

Overview

Research Study Summary

A clinical trial seeking patients for a research study for the treatment of Anaemia

Research Study Title

A Phase 3 Randomized, Open-label (Sponsor-blind), Active-controlled, Parallel-group, Multi-center, Event Driven Study in Non-dialysis Subjects With Anemia Associated With Chronic Kidney Disease to Evaluate the Safety and Efficacy of Daprodustat Compared to Darbepoetin Alfa

Purpose

The purpose of this multi-center event-driven study in non-dialysis (ND) participants with anemia associated with chronic kidney disease (CKD) is to evaluate the safety and efficacy of daprodustat compared to darbepoetin alfa.

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Recruitment Details

Phase
3
Gender
All
Age
18 to 99 Years
Overall Status
Recruiting
Lead Sponsor
GlaxoSmithKline
Duration
52 Months
Facility Type
N/A
Compensation

Eligibility

All ages 18 Years to 99 Years

Inclusion Criteria:

  • Age: 18 to 99 years of age (inclusive).

  • CKD stage: Kidney Disease Outcomes Quality Initiative (KDOQI) CKD stages 3, 4, or 5 defined by electronic estimated glomerular filtration rate (eGFR) using the CKD Epidemiology Collaboration (CKD-EPI) formula.

  • Erythropoietin-stimulating agents (ESAs)/Hgb: Group 1 (not using ESAs): No ESA use within the 6 weeks prior to screening and no ESA use between screening and randomization (Day 1). Hgb concentration: On randomization (Day 1): Hgb 8 to 10 grams (g)/deciliter (dL). Group 2 (ESA users): Use of any approved ESA for the 6 weeks prior to screening and continuing between screening and randomization. Hgb concentration: On randomization (Day 1): Hgb 8 to 11 g/dL and receiving at least the minimum ESA dose.

  • Compliance with placebo [randomization (Day 1) only]: > =80% and < =120% compliance with placebo during run-in period.

  • Informed consent: capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the consent form and in this protocol.

Exclusion Criteria:

  • Dialysis: On dialysis or clinical evidence of impending need to initiate dialysis within 90 days after study start (Day 1).

  • Ferritin: < =100 nanograms (ng)/milliliter (mL) ( < =100 micrograms/liter [L]) at screening.

  • Transferrin saturation (TSAT) (screening only): < =20%.

  • Aplasias: History of bone marrow aplasia or pure red cell aplasia.

  • Other causes of anemia: Pernicious anemia, thalassemia major, sickle cell disease or myelodysplastic syndrome.

  • Gastrointestinal (GI) bleeding: Evidence of actively bleeding gastric, duodenal, or esophageal ulcer disease or clinically significant GI bleeding < =4 weeks prior to screening through to randomization (Day 1).

  • MI or acute coronary syndrome: < =4 weeks prior to screening through to randomization (Day 1).

  • Stroke or transient ischemic attack: < =4 weeks prior to screening through to randomization (Day 1).

  • Heart failure (HF): Chronic Class IV HF, as defined by the New York Heart Association (NYHA) functional classification system.

  • Current uncontrolled hypertension: Current uncontrolled hypertension as determined by the investigator that would contraindicate the use of recombinant human erythropoietin (rhEPO).

  • Bazett's corrected QT interval (QTcB) (Day 1): QTcB > 500 millisecond (msec), or QTcB

530 msec in subjects with bundle branch block. There is no Q-T Interval Corrected for Heart Rate (QTc) exclusion for subjects with a predominantly paced rhythm.

  • Alanine transaminase (ALT): > 2x upper limit of normal (ULN) at screening.

  • Bilirubin: > 1.5xULN at screening.

  • Current unstable liver or biliary disease per investigator assessment, generally defined by the presence of ascites, encephalopathy, coagulopathy, hypoalbuminaemia, esophageal or gastric varices, persistent jaundice, or cirrhosis.

  • Malignancy: History of malignancy within the 2 years prior to screening through to randomization (Day 1) or currently receiving treatment for cancer, or complex kidney cyst (example [e.g.] Bosniak Category II F, III or IV) > 3 centimeter (cm); with the exception of localized squamous cell or basal cell carcinoma of the skin that has been definitively treated > =4 weeks prior to screening.

  • Severe allergic reactions: History of severe allergic or anaphylactic reactions or hypersensitivity to excipients in the investigational product, or darbepoetin alfa.

  • Drugs and supplements: Use of strong inhibitors of Cytochrome P4502C8 (CYP2C8) (e.g., gemfibrozil) or strong inducers of CYP2C8 (e.g., rifampin/rifampicin).

  • Prior investigational product exposure: Use of an investigational agent < =30 days or within five half lives of the investigational agent (whichever is longer) prior to screening.

  • Prior treatment with daprodustat: Any prior treatment with daprodustat for treatment duration of > 30 days.

  • Females only: Subject is pregnant [as confirmed by a positive urine human chorionic gonadotrophin (hCG) test for females of reproductive potential (FRP) only], subject is breastfeeding, or subject is of reproductive potential and does not agree to follow one of the contraceptive options listed in the List of Highly Effective Methods for Avoiding Pregnancy.

  • Other Conditions: Any other condition, clinical or laboratory abnormality, or examination finding that the investigator considers would put the subject at unacceptable risk, which may affect study compliance (e.g., intolerance to darbepoetin alfa) or prevent understanding of the aims or investigational procedures or possible consequences of the study.

Site Locations (295)

Country State City Zip Facility and Contact
United States Alabama Andalusia 36520 GSK Investigational Site
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United States Alabama Huntsville 35805 GSK Investigational Site
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United States Arizona Avondale 85392 GSK Investigational Site
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United States Arizona Mesa 85202 GSK Investigational Site
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United States Arizona Phoenix 85016 GSK Investigational Site
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United States Arizona Phoenix 85027 GSK Investigational Site
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United States Arizona Prescott 86301 GSK Investigational Site
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United States Arizona Tucson 85745 GSK Investigational Site
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United States California Bakersfield 93308 GSK Investigational Site
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United States California Bakersfield 93309 GSK Investigational Site
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United States California Chula Vista 91910 GSK Investigational Site
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United States California Cudahy 90201 GSK Investigational Site
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United States California El Centro GSK Investigational Site
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United States California Escondido 92025 GSK Investigational Site
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United States California Glendale 91204 GSK Investigational Site
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United States California Granada Hills 91344 GSK Investigational Site
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United States California La Mesa 91942 GSK Investigational Site
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United States California La Palma 90623 GSK Investigational Site
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United States California Los Angeles 90022 GSK Investigational Site
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United States California Lynwood 90262 GSK Investigational Site
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United States California Montebello 90640 GSK Investigational Site
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United States California National City 91950 GSK Investigational Site
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United States California Riverside 92505 GSK Investigational Site
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United States California San Diego 92103 GSK Investigational Site
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United States California San Diego 92111 GSK Investigational Site
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United States California San Luis Obispo 93405 GSK Investigational Site
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United States California Simi Valley 93065 GSK Investigational Site
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United States California Tarzana 91356 GSK Investigational Site
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United States California Whittier 90602 GSK Investigational Site
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United States Connecticut Middlebury 06762 GSK Investigational Site
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United States District of Columbia Washington, D.C. 20037 GSK Investigational Site
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United States Florida Aventura 33180 GSK Investigational Site
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United States Florida Boca Raton 33431 GSK Investigational Site
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United States Florida Coral Gables 33134 GSK Investigational Site
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United States Florida Cutler Bay 33189 GSK Investigational Site
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United States Florida Doral 33122 GSK Investigational Site
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United States Florida Fort Lauderdale 33308 GSK Investigational Site
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United States Florida Hudson 34667 GSK Investigational Site
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United States Florida Jacksonville 32256 GSK Investigational Site
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United States Florida Lauderdale Lakes 33313 GSK Investigational Site
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United States Florida Miami Gardens 33169 GSK Investigational Site
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United States Florida Miami Lakes 33014 GSK Investigational Site
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United States Florida Miami 33126 GSK Investigational Site
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United States Florida Miami 33133 GSK Investigational Site
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United States Florida Miami 33143 GSK Investigational Site
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United States Florida Miami 33145 GSK Investigational Site
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United States Florida Miami 33150 GSK Investigational Site
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United States Florida Miami 33155 GSK Investigational Site
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United States Florida Miami 33156 GSK Investigational Site
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United States Florida Miami 33165 GSK Investigational Site
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United States Florida Miami 33169 GSK Investigational Site
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United States Florida Miami 33173 GSK Investigational Site
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United States Florida Ocala 34471 GSK Investigational Site
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United States Florida Pembroke Pines 33028 GSK Investigational Site
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United States Florida Port Charlotte 33952 GSK Investigational Site
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United States Florida South Miami 33143 GSK Investigational Site
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United States Georgia Atlanta 30342 GSK Investigational Site
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United States Georgia Augusta 30909 GSK Investigational Site
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United States Georgia Columbus 31904 GSK Investigational Site
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United States Idaho Meridian 83642 GSK Investigational Site
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United States Illinois Crystal Lake 60014 GSK Investigational Site
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United States Illinois Evergreen Park 60805 GSK Investigational Site
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United States Illinois Mount Prospect 60056 GSK Investigational Site
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United States Illinois Springfield 62702 GSK Investigational Site
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United States Indiana Fort Wayne 46845 GSK Investigational Site
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United States Indiana Jeffersonville 47130 GSK Investigational Site
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United States Indiana Michigan City 46360 GSK Investigational Site
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United States Iowa Iowa City 52242 GSK Investigational Site
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United States Kansas Hutchinson 67502 GSK Investigational Site
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United States Kansas Wichita 67214 GSK Investigational Site
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United States Louisiana Baton Rouge 70808 GSK Investigational Site
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United States Louisiana Metairie 70006 GSK Investigational Site
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United States Maryland Rockville 20852 GSK Investigational Site
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United States Maryland Takoma Park 20912-6385 GSK Investigational Site
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United States Massachusetts Boston 02114 GSK Investigational Site
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United States Michigan Detroit 48202 GSK Investigational Site
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United States Michigan Kalamazoo 49007 GSK Investigational Site
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United States Michigan Pontiac 48341 GSK Investigational Site
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United States Mississippi Tupelo 38801 GSK Investigational Site
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United States Missouri Saint Louis 63110 GSK Investigational Site
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United States Nebraska North Platte 69101 GSK Investigational Site
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United States Nevada Las Vegas 89115 GSK Investigational Site
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United States New York Brooklyn 11203 GSK Investigational Site
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United States New York Laurelton 11413 GSK Investigational Site
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United States New York Ridgewood 11385 GSK Investigational Site
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United States New York The Bronx 10461 GSK Investigational Site
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United States New York Yonkers 10704 GSK Investigational Site
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United States North Carolina Raleigh 27609 GSK Investigational Site
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United States North Carolina Wilmington 28401 GSK Investigational Site
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United States North Carolina Winston-Salem 27103 GSK Investigational Site
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United States North Dakota Grand Forks 58201 GSK Investigational Site
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United States Ohio Canton 44718 GSK Investigational Site
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United States Ohio Mentor 44060 GSK Investigational Site
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United States Oregon Portland 97210 GSK Investigational Site
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United States Oregon Roseburg 97471 GSK Investigational Site
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United States Pennsylvania Bethlehem 18017 GSK Investigational Site
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United States South Carolina Anderson 29621 GSK Investigational Site
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United States South Carolina Charleston 29425 GSK Investigational Site
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United States South Carolina Sumter 29150 GSK Investigational Site
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United States Tennessee Cordova 38018 GSK Investigational Site
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United States Tennessee Knoxville 37923 GSK Investigational Site
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United States Tennessee Nashville 37205 GSK Investigational Site
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United States Texas Austin 78751 GSK Investigational Site
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United States Texas Austin 78758 GSK Investigational Site
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United States Texas Corpus Christi 78404 GSK Investigational Site
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United States Texas Corsicana 75110 GSK Investigational Site
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United States Texas Dallas 75246 GSK Investigational Site
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United States Texas Houston 77043 GSK Investigational Site
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United States Texas Houston 77084 GSK Investigational Site
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United States Texas Houston 77099 GSK Investigational Site
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United States Texas Lufkin 75904 GSK Investigational Site
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United States Texas McAllen 78503 GSK Investigational Site
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United States Texas San Antonio 78202 GSK Investigational Site
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United States Texas San Antonio 78229 GSK Investigational Site
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United States Virginia Alexandria 22304 GSK Investigational Site
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United States Virginia Fairfax 22033 GSK Investigational Site
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United States Virginia Hampton 23666 GSK Investigational Site
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United States Virginia Salem 24153 GSK Investigational Site
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United States West Virginia Bluefield 24701 GSK Investigational Site
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Argentina Buenos Aires Coronel Suarez GSK Investigational Site
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Argentina Buenos Aires Junín B6000GMA GSK Investigational Site
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Argentina Buenos Aires Mar del Plata GSK Investigational Site
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Argentina Buenos Aires Pergamino B2700CPM GSK Investigational Site
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Argentina Córdova Cordoba 5000 GSK Investigational Site
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Argentina Buenos Aires 1425 GSK Investigational Site
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Argentina Formosa P3600LLD GSK Investigational Site
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Argentina La Plata B1902COS GSK Investigational Site
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Argentina San Miguel de Tucumán T4000AHL GSK Investigational Site
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Australia New South Wales Gosford 2250 GSK Investigational Site
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Australia New South Wales Wollongong 2500 GSK Investigational Site
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Australia Queensland Nambour 4560 GSK Investigational Site
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Australia Victoria Reservoir 3073 GSK Investigational Site
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Australia Victoria St Albans 3021 GSK Investigational Site
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Belgium Aalst 9300 GSK Investigational Site
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Belgium Ieper 8900 GSK Investigational Site
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Belgium Leuven 3000 GSK Investigational Site
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Belgium Liège 4000 GSK Investigational Site
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Belgium Sint-Niklaas 9100 GSK Investigational Site
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Brazil Paraná Curitiba 80730-150 GSK Investigational Site
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Brazil Rio Grande Do Sul Passo Fundo 99010-080 GSK Investigational Site
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Brazil Rio Grande Do Sul Porto Alegre 90035-074 GSK Investigational Site
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Brazil Rio Grande Do Sul Porto Alegre 90035-903 GSK Investigational Site
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Brazil Rio Grande Do Sul Porto Alegre 90610-000 GSK Investigational Site
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Brazil São Paulo Sao Jose do Rio Preto 15090-000 GSK Investigational Site
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Brazil São Paulo Votuporanga 15500-003 GSK Investigational Site
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Brazil Curitiba 80440-020 GSK Investigational Site
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Brazil Feira de Santana 44001-465 GSK Investigational Site
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Brazil Joinville 89201-010 GSK Investigational Site
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Brazil Juiz De Fora 36036-330 GSK Investigational Site
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Brazil Salvador 40415-065 GSK Investigational Site
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Brazil Sao Paulo 01323-001 GSK Investigational Site
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Brazil São Paulo 01323903 GSK Investigational Site
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Brazil São Paulo 04039-000 GSK Investigational Site
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Bulgaria Blagoevgrad 2700 GSK Investigational Site
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Bulgaria Gabrovo 5300 GSK Investigational Site
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Bulgaria Lom 3600 GSK Investigational Site
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Bulgaria Smolyan 4700 GSK Investigational Site
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Canada Ontario Brampton L6T 0G1 GSK Investigational Site
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Canada Ontario Mississauga L4V 1P1 GSK Investigational Site
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Czechia Beroun 26601 GSK Investigational Site
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Czechia Cesky Krumlov 38127 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Czechia Marianske Lazne 353 01 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Czechia Sokolov 356 01 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Denmark Aalborg DK-9000 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Denmark Kolding 6000 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Estonia Jämejala village 71024 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Estonia Tartu GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
France Annonay 07103 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
France Saint-Ouen 93400 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Germany Schleswig-Holstein Kiel 24105 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Germany Duesseldorf 40210 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Greece Alexandroupolis 68100 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Greece Arta 471 00 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Greece Athens 115 26 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Greece Athens 11526 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Greece Athens 11527 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Greece Athens 12462 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Greece Heralkion 71409 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Greece Ioannina 45500 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Greece Larissa 41110 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Greece Patras 26500 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Greece Thessaloniki 54636 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Greece Thessaloniki 551 34 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Greece Thessaloniki 56403 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Greece Thessaloniki 57001 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Greece Thessaloniki 57010 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Hungary Baja 6500 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Hungary Esztergom 2500 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Hungary Kecskemét 6000 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Hungary Pecs 7623 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Italy Calabria Catanzaro 88100 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Italy Lombardia Milano 20132 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Italy Lombardia Pavia 27100 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Anyang-Si Gyeonggi-do 431-070 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Bucheon 420-767 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Daegu-si 700-710 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Daegu 41944 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Daejeon 301-721 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Goyang-si, Gyeonggi-do 411706 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Goyang-si 410-719 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Seongnam 13620 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Seoul 08308 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Seoul 110-744 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Seoul 134-727 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Seoul 135-710 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Seoul 137-701 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Seoul 05355 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Seoul 07061 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Suwon 440-380 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Uijeongbu-si 11765 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Korea, Republic of Wonju-si 26426 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Mexico Coahuila Torreon 27000 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Mexico Durango Durango. 34000 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Mexico Guanajuato Leon 37530 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Mexico Guanajuato León 37000 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Mexico Jalisco Guadalajara. 44600 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Mexico Jalisco Guadalajara 44620 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Mexico Morelos Cuernavaca 62448 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Mexico Querétaro Queretaro 76000 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Mexico Sinaloa Culiacan 80200 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Mexico Sinaloa Mazatlán 82020 GSK Investigational Site
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GSKClinicalSupportHD@gsk.com
Mexico Yucatán Merida 97070 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Mexico Yucatán Merida 97133 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Mexico Chihuahua 31217 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Mexico Ciudad De México 06100 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Mexico Ciudad De México 03800 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Mexico Tlalnepantla De Baz 54055 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Mexico Zapopan, Jalisco 45030 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
New Zealand Hamilton 2001 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
New Zealand Otahuhu 1640 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Philippines San Juan 1500 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Poland Bialystok 15-540 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Poland Kolobrzeg 78-100 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Poland Lódz 92-213 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Portugal Amadora 2720-276 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Portugal Aveiro 3814-501 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Romania Bucharest 022328 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Romania Bucharest 022328 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Romania Bucuresti 022328 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Romania Constanta 900591 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Romania Oradea 410469 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Romania Timisoara 300723 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Russian Federation Irkutsk 664049 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Russian Federation Kemerovo 650060 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Russian Federation Moscow 125315 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Russian Federation Mytischi 141009 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Russian Federation Omsk 644112 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Russian Federation Smolensk 214006 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Russian Federation St. Petersburg 196247 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Russian Federation Ulyanovsk 432063 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Russian Federation Volzhsky 404120 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Russian Federation Yaroslavl 150062 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
South Africa Cape Town 7129 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Spain Madrid Majadahonda 28222 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Spain Barcelona 08003 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Spain Barcelona 08035 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Spain Burela 27880 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Spain Girona 17007 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Spain L'Hospitalet de Llobregat 08907 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Spain Sevilla 41071 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Taiwan Kaohsiung 807 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Taiwan Keelung 204 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Taiwan Taipei 100 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Taiwan Taipei 104 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Taiwan Taipei 116 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Thailand Bangkoknoi 10700 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Thailand Bangkok 10330 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Thailand Bangkok 10400 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Thailand Bangkok 11000 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Thailand Muang 50200 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Thailand Pathumthani 12120 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Ukraine Chernivtsi 58005 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Ukraine Ivano-Frankivsk 76008 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Ukraine Kharkiv 61039 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Ukraine Kherson 73039 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Ukraine Kiev 04107 GSK Investigational Site
US GSK Clinical Trials Call Center
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GSKClinicalSupportHD@gsk.com
Ukraine Kyiv GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Ukraine Kyiv 01014 GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
Ukraine Kyiv 01023 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Ukraine Kyiv 04050 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Ukraine Lutsk 43000 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Ukraine Ternopil 46002 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Ukraine Zaporizhzhia 69600 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Ukraine Zaporizhzhya 69118 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
Ukraine Zhytomyr 10002 GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
United Kingdom London Hampstead NW3 2QG GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
United Kingdom Cardiff CF14 4XW GSK Investigational Site
US GSK Clinical Trials Call Center
877-379-3718
GSKClinicalSupportHD@gsk.com
United Kingdom Derby DE22 3NE GSK Investigational Site
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GSKClinicalSupportHD@gsk.com
United Kingdom Fife KY2 5AH GSK Investigational Site
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GSKClinicalSupportHD@gsk.com
United Kingdom Leeds LS9 7TF GSK Investigational Site
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877-379-3718
GSKClinicalSupportHD@gsk.com
United Kingdom London SE22 8PT GSK Investigational Site
US GSK Clinical Trials Call Center
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GSKClinicalSupportHD@gsk.com
United Kingdom Middlesbrough TS4 3BW GSK Investigational Site
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GSKClinicalSupportHD@gsk.com
United Kingdom Oxford OX3 7LE GSK Investigational Site
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GSKClinicalSupportHD@gsk.com
United Kingdom Salford M6 8HD GSK Investigational Site
US GSK Clinical Trials Call Center
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United Kingdom York YO31 8HE GSK Investigational Site
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