Clinical Trial Details

NCT ID: NCT02792231
Date Last Changed: September 19, 2017

Overview

Research Study Summary

A clinical trial seeking patients for a research study for the treatment of Relapsing Multiple Scelrosis

Research Study Title

A Randomized, Double-blind, Double-dummy, Parallel-group Study Comparing the Efficacy and Safety of Ofatumumab Versus Teriflunomide in Patients With Relapsing Multiple Sclerosis.

Purpose

To compare the efficacy and safety of ofatumumab administered subcutaneously (sc) every 4 weeks versus teriflunomide administered orally once daily in patients with relapsing multiple sclerosis

To Learn more

Recruitment Details

Phase
3
Gender
All
Age
18 to 55 Years
Overall Status
Recruiting
Lead Sponsor
Novartis Pharmaceuticals
Duration
33 Months
Facility Type
N/A
Compensation

Eligibility

All ages 18 Years to 55 Years

Inclusion Criteria:

  • Diagnosis of multiple sclerosis (MS)

  • Relapsing MS (RRMS or SPMS) course

  • At least 1 relapse during the previous 1 year or 2 relapses during the previous 2 years or a positive gadolinium-enhancing MRI scan in previous year

  • EDSS score of 0 to 5.5

Exclusion Criteria:

  • Primary progressive MS

  • Disease duration of more than 10 years in patients with an EDSS score of 2 or less

  • Patients with an active chronic disease of the immune system other than MS

  • Patients at risk of developing or having reactivation of hepatitis

  • Patients with active systemic infections or with neurological findings consistent with PML

Other protocol-defined inclusion/exclusion criteria may apply

Site Locations (196)

Country State City Zip Facility and Contact
United States Alabama Birmingham 35233-0271 Novartis Investigative Site
United States Alabama Cullman 35058 Novartis Investigative Site
United States Arizona Phoenix 85018 Novartis Investigative Site
United States Arizona Tucson 85704 Novartis Investigative Site
United States Arizona Tucson 85718 Novartis Investigative Site
United States Colorado Aurora 80045 Novartis Investigative Site
United States Colorado Basalt 81621 Novartis Investigative Site
United States Colorado Boulder 80301 Novartis Investigative Site
United States Colorado Centennial 80112 Novartis Investigative Site
United States Colorado Colorado Springs 80907 Novartis Investigative Site
United States Colorado Denver 80210 Novartis Investigative Site
United States Colorado Fort Collins 80528 Novartis Investigative Site
United States Colorado Fort Collins 907-280528 Novartis Investigative Site
United States Connecticut Fairfield 06824 Novartis Investigative Site
United States Delaware Newark 19713 Novartis Investigative Site
United States Florida Bradenton 34205 Novartis Investigative Site
United States Florida Maitland 32751 Novartis Investigative Site
United States Florida Ocala 34471 Novartis Investigative Site
United States Florida Oldsmar 34677 Novartis Investigative Site
United States Florida Ormond Beach 32174 Novartis Investigative Site
United States Florida Palm Coast 32164 Novartis Investigative Site
United States Florida Saint Petersburg 33713 Novartis Investigative Site
United States Florida Sarasota 34243 Novartis Investigative Site
United States Florida Tallahassee 32312 Novartis Investigative Site
United States Florida Tampa 33603 Novartis Investigative Site
United States Florida Tampa 33609 Novartis Investigative Site
United States Florida Tampa 33612 Novartis Investigative Site
United States Georgia Atlanta 30309 Novartis Investigative Site
United States Georgia Suwanee 30024 Novartis Investigative Site
United States Illinois Flossmoor 60422 Novartis Investigative Site
United States Indiana Anderson 46011 Novartis Investigative Site
United States Indiana Indianapolis 46256 Novartis Investigative Site
United States Maryland Baltimore 21201 Novartis Investigative Site
United States Massachusetts Boston 02135 Novartis Investigative Site
United States Massachusetts Foxborough 02035 Novartis Investigative Site
United States Massachusetts Lexington 02421 Novartis Investigative Site
United States Massachusetts Worcester 01655 Novartis Investigative Site
United States Michigan Detroit 48202 Novartis Investigative Site
United States Michigan Farmington Hills 48334 Novartis Investigative Site
United States Michigan Grand Rapids 49503 Novartis Investigative Site
United States Minnesota Golden Valley 55422 Novartis Investigative Site
United States Montana Billing 59101 Novartis Investigative Site
United States Montana Great Falls 59405 Novartis Investigative Site
United States Nebraska Omaha 68198-2045 Novartis Investigative Site
United States New Jersey Freehold 07728 Novartis Investigative Site
United States New Mexico Albuquerque 87131-0001 Novartis Investigative Site
United States New York Plainview 11803 Novartis Investigative Site
United States North Carolina Asheville 28806 Novartis Investigative Site
United States North Carolina Charlotte 28202 Novartis Investigative Site
United States North Carolina Greensboro 27405 Novartis Investigative Site
United States North Carolina Hendersonville 28792 Novartis Investigative Site
United States Ohio Columbus 43214 Novartis Investigative Site
United States Ohio Columbus 43221 Novartis Investigative Site
United States Ohio Toledo 43614 Novartis Investigative Site
United States Ohio Uniontown 44685 Novartis Investigative Site
United States Oregon Portland 97225 Novartis Investigative Site
United States Oregon Springfield 97477 Novartis Investigative Site
United States Pennsylvania Hershey 17033-0850 Novartis Investigative Site
United States Pennsylvania Pittsburgh 15212 Novartis Investigative Site
United States Pennsylvania Willow Grove 19090 Novartis Investigative Site
United States South Carolina Greer 29650 Novartis Investigative Site
United States Tennessee Knoxville 37934 Novartis Investigative Site
United States Tennessee Nashville 37205 Novartis Investigative Site
United States Tennessee Nashville 37212 Novartis Investigative Site
United States Texas Greenville 75401 Novartis Investigative Site
United States Texas Lubbock 79410 Novartis Investigative Site
United States Texas Sherman 75092 Novartis Investigative Site
United States Utah Orem 84058 Novartis Investigative Site
United States Utah Salt Lake City 84103 Novartis Investigative Site
United States Utah Salt Lake City 84132 Novartis Investigative Site
United States Washington Kirkland 98034 Novartis Investigative Site
United States Washington Seattle 98101 Novartis Investigative Site
United States Washington Seattle 98122 Novartis Investigative Site
United States Washington Seattle 98133 Novartis Investigative Site
United States Wisconsin Waukesha 53188 Novartis Investigative Site
Argentina Buenos Aires Caba C1181ACH Novartis Investigative Site
Argentina Buenos Aires Caba C1428AQK Novartis Investigative Site
Argentina Santa Fe Rosario S2000DSW Novartis Investigative Site
Argentina Tucuman 4000 Novartis Investigative Site
Australia New South Wales Camperdown 2050 Novartis Investigative Site
Australia New South Wales Liverpool 2170 Novartis Investigative Site
Australia Victoria Melbourne 3050 Novartis Investigative Site
Austria Innsbruck 6020 Novartis Investigative Site
Austria Vienna 1010 Novartis Investigative Site
Austria Vienna 1090 Novartis Investigative Site
Belgium Aalst 9300 Novartis Investigative Site
Belgium Bruxelles 1200 Novartis Investigative Site
Belgium Edegem 2650 Novartis Investigative Site
Belgium Gent 9000 Novartis Investigative Site
Belgium La Louviere 7100 Novartis Investigative Site
Bulgaria Sofia 1113 Novartis Investigative Site
Bulgaria Sofia 1413 Novartis Investigative Site
Canada Ontario London N6A 5A5 Novartis Investigative Site
Canada Ontario Ottowa K1H 8L6 Novartis Investigative Site
Canada Ontario Toronto M4N 3M5 Novartis Investigative Site
Canada Quebec Greenfield Park J4V 2J2 Novartis Investigative Site
Croatia Osijek 31000 Novartis Investigative Site
Croatia Zagreb 10000 Novartis Investigative Site
Czechia Czech Republic Brno 656 91 Novartis Investigative Site
Czechia Czech Republic Havirov 736 01 Novartis Investigative Site
Czechia Czech Republic Teplice 415 01 Novartis Investigative Site
Czechia Ostrava-Poruba 708 52 Novartis Investigative Site
Finland Turku 20520 Novartis Investigative Site
Finland Turku 20521 Novartis Investigative Site
France Cedex1 Nice 06001 Novartis Investigative Site
France Bordeaux Cedex 33076 Novartis Investigative Site
France Clermont-Ferrand 63000 Novartis Investigative Site
France Montpellier 34295 Novartis Investigative Site
France Paris Cedex 13 75651 Novartis Investigative Site
France Rennes Cedex 35033 Novartis Investigative Site
France Strasbourg 67098 Novartis Investigative Site
Germany Berlin 10098 Novartis Investigative Site
Germany Berlin 12101 Novartis Investigative Site
Germany Bochum 44791 Novartis Investigative Site
Germany Bonn 53111 Novartis Investigative Site
Germany Dresden 01307 Novartis Investigative Site
Germany Erbach 64711 Novartis Investigative Site
Germany Erfurt 99089 Novartis Investigative Site
Germany Erlangen 91054 Novartis Investigative Site
Germany Essen 45147 Novartis Investigative Site
Germany Hamburg 22179 Novartis Investigative Site
Germany Heidelberg 69120 Novartis Investigative Site
Germany Homburg 66421 Novartis Investigative Site
Germany Koln 50935 Novartis Investigative Site
Germany Leipzig 04103 Novartis Investigative Site
Germany Leipzig 04107 Novartis Investigative Site
Germany Minden 32429 Novartis Investigative Site
Germany Siegen 57076 Novartis Investigative Site
Germany Stuttgart 70182 Novartis Investigative Site
Germany Ulm 89081 Novartis Investigative Site
Germany Unterhaching 82008 Novartis Investigative Site
Hungary HUN Budapest 1204 Novartis Investigative Site
Hungary HUN Esztergom 2500 Novartis Investigative Site
Hungary Budapest 1145 Novartis Investigative Site
India Delhi New Delhi 110 060 Novartis Investigative Site
India Maharashtra Pune 411004 Novartis Investigative Site
India Mumbai 400016 Novartis Investigative Site
Italy IS Pozzilli 86077 Novartis Investigative Site
Italy Genova 16132 Novartis Investigative Site
Italy Milano 20133 Novartis Investigative Site
Latvia LV Riga LV-1005 Novartis Investigative Site
Latvia Riga LV 1002 Novartis Investigative Site
Latvia Riga LV-1038 Novartis Investigative Site
Lithuania LTU Kaunas 50009 Novartis Investigative Site
Lithuania Vilnius LT-08661 Novartis Investigative Site
Norway Drammen 1086 Novartis Investigative Site
Norway Stavanger 4068 Novartis Investigative Site
Poland Glogow 36-060 Novartis Investigative Site
Poland Rzeszow 35-055 Novartis Investigative Site
Poland Wroclaw 51-685 Novartis Investigative Site
Poland Zabrze 41-800 Novartis Investigative Site
Portugal Porto Matosinhos 4454509 Novartis Investigative Site
Portugal Amadora 2720-276 Novartis Investigative Site
Portugal Braga 4710243 Novartis Investigative Site
Portugal Coimbra 3000-075 Novartis Investigative Site
Portugal Lisboa 1169-050 Novartis Investigative Site
Portugal Lisboa 1500-650 Novartis Investigative Site
Portugal Lisboa 1600190 Novartis Investigative Site
Portugal Loures 2674514 Novartis Investigative Site
Portugal Porto 4000001 Novartis Investigative Site
Portugal Porto 4200 319 Novartis Investigative Site
Portugal Santa Maria Da Feira 4520211 Novartis Investigative Site
Russian Federation Ekaterinburg 620102 Novartis Investigative Site
Russian Federation Kazan 420021 Novartis Investigative Site
Russian Federation Krasnoyarsk 660037 Novartis Investigative Site
Russian Federation Moscow 127015 Novartis Investigative Site
Russian Federation Nizhny Novgorod 603137 Novartis Investigative Site
Russian Federation Novosibirsk 630087 Novartis Investigative Site
Russian Federation Saint Petersburg 197022 Novartis Investigative Site
Russian Federation St. Petersburg 197110 Novartis Investigative Site
Russian Federation St. Petersburg 197376 Novartis Investigative Site
Slovakia Bratislava 813 69 Novartis Investigative Site
Slovakia Martin 036 59 Novartis Investigative Site
Slovakia Ruzomberok 03426 Novartis Investigative Site
South Africa Rosebank 2196 Novartis Investigative Site
Spain Andalucia Malaga 29010 Novartis Investigative Site
Spain Andalucia Sevilla 41017 Novartis Investigative Site
Spain Madrid Majadahonda 28222 Novartis Investigative Site
Spain Madrid Pozuelo de Alarcon 28223 Novartis Investigative Site
Spain Madrid 28034 Novartis Investigative Site
Spain Madrid 28040 Novartis Investigative Site
Spain San Sebastian 20014 Novartis Investigative Site
Switzerland Aarau 5001 Novartis Investigative Site
Switzerland Bern 3010 Novartis Investigative Site
Switzerland Lugano 6900 Novartis Investigative Site
Taiwan Taichung 40447 Novartis Investigative Site
Taiwan Tainan 70421 Novartis Investigative Site
Turkey Balcova / Izmir 35340 Novartis Investigative Site
Turkey Haseki / Istanbul 34096 Novartis Investigative Site
Turkey Mersin 33079 Novartis Investigative Site
Turkey Trabzon 61080 Novartis Investigative Site
United Kingdom Beds Luton LU4 0DZ Novartis Investigative Site
United Kingdom Essex Romford RM7 0AG Novartis Investigative Site
United Kingdom South Yorkshire Sheffield S10 2JF Novartis Investigative Site
United Kingdom London SE5 9RS Novartis Investigative Site
United Kingdom London SW17 0QT Novartis Investigative Site

Contact

Novartis Pharmaceuticals
1-888-669-6682

DISCLAIMER: CenterWatch does not conduct clinical research. CenterWatch is a publishing company that posts clinical trials information on behalf of sponsor companies, contract research organizations, clinical research sites and other interested parties. This information is designed to help patients find clinical trials of interest and contact the research centers conducting the trials.