Clinical Trial Details

NCT ID: NCT02668653
Date Last Changed: September 28, 2017

Overview

Research Study Summary

A clinical trial seeking patients for a research study for the treatment of Acute Myeloid Leukemia or Leukemia

Research Study Title

A Phase 3, Double-Blind, Placebo-controlled Study of Quizartinib Administered in Combination With Induction and Consolidation Chemotherapy, and Administered as Maintenance Therapy in Subjects 18 to 75 Years Old With Newly Diagnosed FLT3-ITD (+) Acute Myeloid Leukemia

Purpose

This is a phase 3, randomized, double-blind, placebo-control global study. The purpose of this study is to compare the effect of quizartinib versus placebo (administered with standard induction and consolidation chemotherapy, then administered as maintenance therapy for up to 12 cycles) on event-free survival in subjects with FLT3-internal tandem duplication (ITD) positive AML.

To Learn more

Recruitment Details

Phase
3
Gender
All
Age
18 to 75 Years
Overall Status
Recruiting
Lead Sponsor
Daiichi Sankyo, Inc.
Duration
50 Months
Facility Type
N/A
Compensation

Eligibility

All ages 18 Years to 75 Years

Inclusion Criteria:

  1. Must be competent and able to comprehend, sign, and date an Ethics Committee (EC) or Institutional Review Board approved Informed Consent Form (ICF) before performance of any study-specific procedures or tests;

  2. Is ≥18 years or the minimum legal adult age (whichever is greater) and ≤75 years (at Screening);

  3. Newly diagnosed, morphologically documented primary AML or AML secondary to myelodysplastic syndrome or a myeloproliferative neoplasm, based on the World Health Organization (WHO) 2008 classification (at Screening);

  4. Eastern Cooperative Oncology Group (ECOG) performance status 0-2 (at the time the subject signs their first informed consent form);

  5. Presence of FLT3-ITD activating mutation in bone marrow (allelic ratio of ≥3% FLT3-ITD/total FLT3);

  6. Participant is receiving standard "7+3" induction chemotherapy regimen as specified in the protocol;

  7. Adequate renal function defined as:

a. Creatinine clearance > 50 mL/min, as calculated with the modified Cockcroft Gault equation

  1. Adequate hepatic function defined as:

  2. Total serum bilirubin (TBL) ≤1.5 × upper limit of normal (ULN);

  3. Serum alkaline phosphatase, aspartate transaminase (AST) and alanine transaminase (ALT) ≤2.5 × ULN;

  4. Serum electrolytes within normal limits: potassium, calcium (total, or corrected for serum albumin in case of hypoalbuminemia) and magnesium. If outside of normal limits, subject will be eligible when electrolytes are corrected;

  5. If a woman of childbearing potential, must have a negative serum pregnancy test upon entry into this study and must be willing to use highly effective birth control upon enrollment, during the treatment period and for 6 months following the last dose of investigational drug or cytarabine, whichever is later. A woman is considered of childbearing potential following menarche and until becoming postmenopausal (no menstrual period for a minimum of 12 months);

  6. If male, must be surgically sterile or willing to use highly effective birth control upon enrollment, during the treatment period, and for 6 months following the last dose of investigational drug or cytarabine, whichever is later.

Exclusion Criteria:

  1. Diagnosis of acute promyelocytic leukemia (APL), French-American-British classification M3 or WHO classification of APL with translocation, t(15;17)(q22;q12), or breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL) positive leukemia (ie, chronic myelogenous leukemia in blast crisis); subjects who undergo diagnostic workup for APL and treatment with all-trans retinoic acid (ATRA), but who are found not to have APL, are eligible (treatment with ATRA must be discontinued before starting induction chemotherapy).

  2. Diagnosis of AML secondary to prior chemotherapy or radiotherapy for other neoplasms;

  3. Prior treatment for AML, except for the following allowances:

  4. Leukapheresis;

  5. Treatment for hyperleukocytosis with hydroxyurea;

  6. Cranial radiotherapy for central nervous system (CNS) leukostasis;

  7. Prophylactic intrathecal chemotherapy;

  8. Growth factor/cytokine support;

  9. Prior treatment with quizartinib or other FLT3-ITD inhibitors;

  10. Prior treatment with any investigational drug or device within 30 days prior to Randomization (within 2 weeks for investigational or approved immunotherapy) or currently participating in other investigational procedures;

  11. History of known CNS leukemia, including cerebrospinal fluid positive for AML blasts; lumbar puncture is recommended for subjects with symptoms of CNS leukemia to rule out extramedullary CNS involvement;

  12. History of other malignancies, except adequately treated non-melanoma skin cancer, curatively treated in-situ disease, or other solid tumors curatively treated with no evidence of disease for at least 2 years;

  13. Uncontrolled or significant cardiovascular disease, including any of the following:

  14. Bradycardia of less than 50 beats per minute, unless the subject has a pacemaker;

  15. Fridericia's Heart Rate Correction Formula (QTcF) interval > 450 msec;

  16. Diagnosis of or suspicion of long QT syndrome (including family history of long QT syndrome);

  17. Systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg;

  18. History of clinically relevant ventricular arrhythmias (eg, ventricular tachycardia, ventricular fibrillation, or Torsade de Pointes);

  19. History of second (Mobitz II) or third degree heart block (subjects with pacemakers are eligible if they have no history of fainting or clinically relevant arrhythmias while using the pacemaker);

  20. History of uncontrolled angina pectoris or myocardial infarction within 6 months prior to Screening;

  21. History of New York Heart Association Class 3 or 4 heart failure;

  22. Known history of left ventricular ejection fraction (LVEF) ≤45% or less than the institutional lower limit of normal;

  23. Complete left bundle branch block;

  24. Active acute or chronic systemic fungal, bacterial, or viral infection not well controlled by antifungal, antibacterial or antiviral therapy;

  25. Known active clinically relevant liver disease (eg, active hepatitis B, or active hepatitis C);

  26. Known history of human immunodeficiency virus (HIV). Subjects should be tested for HIV prior to Randomization if required by local regulations or EC;

  27. History of hypersensitivity to any excipients in the quizartinib/placebo tablets;

  28. Females who are pregnant or breastfeeding;

  29. Otherwise considered inappropriate for the study by the Investigator.

Site Locations (197)

Country State City Zip Facility and Contact
United States Alabama Birmingham 35249 The University of Alabama at Birmingham
Site Coordinator
501-590-1946
United States Arizona Tucson 85724 The University of Arizona Cancer Center
Site Coordinator
800-562-4789
United States California Los Angeles 90095 Ronald Reagan UCLA Medical Center
Site Coordinator
310-794-0137
United States Florida Gainesville 90095-7170 University of Florida (UF) Health Shands Hospital
Site Coordinator
352-273-6840
United States Illinois Chicago 60612 Rush University Medical Center
Site Coordinator
312-563-2363
United States Illinois Chicago 60637 The University of Chicago Medical Center
Site Coordinator
773-702-6505
United States Indiana Indianapolis 46237 Franciscan St. Francis Health Indianapolis
Site Coordinator
317-528-7822
United States Kentucky Lexington 40536-0293 University of Kentucky Chandler Medical Center
Site Coordinator
859-323-6969
United States Louisiana Shreveport 71130 Louisiana State University Health Sciences Center Shreveport
Site Coordinator
318-813-1404
United States New Jersey Hackensack 07601 Hackensack Univ. Medical Center
Site Coordinator
551-996-8137
United States North Carolina Durham 27710 Duke Clinical Research Institute
Site Coordinator
919-681-5818
United States Ohio Cleveland 44106 University Hospitals Seidman Cancer Center
Site Coordinator
216-844-5071
United States Ohio Cleveland 44195 Cleveland Clinic Foundation
Site Coordinator
216-445-3854
United States Oklahoma Oklahoma City 73117 University of Oklahoma Medical Center
Site Coordinator
405-271-2090
United States Pennsylvania Philadelphia 19104 Hospital of the University of Pennsylvania
Site Coordinator
215-349-8817
United States Pennsylvania Philadelphia 19107-4307 Thomas Jefferson University Hospital
Site Coordinator
215-955-3202
United States Washington Puyallup 98374-2115 John Theurer Cancer Center at Hackensack University Medical Center
Site Coordinator
800-562-4789
United States West Virginia Morgantown 26506 West Virginia University Hospitals, Inc.
Site Coordinator
304-293-5619
Australia New South Wales Waratah 2298 Calvary Mater Newcastle
Site Coordinator
+61 240144892
Australia Queensland Douglas 4814 Townsville Hospital (TTH)
Site Coordinator
+61 744331627
Australia Queensland Woolloongabba 4102 Princess Alexandra Hospital
Site Coordinator
+61 731762557
Australia South Australia Adelaide 5000 Royal Adelaide Hospital
Site Coordinator
+61 882225793
Australia South Australia Bedford Park 5042 Flinders Medical Centre
Site Coordinator
+61 882046293
Australia Western Australia Murdoch 6150 Fiona Stanley Hospital
Site Coordinator
+61 861525403
Belgium Brugge 8000 AZ Sint-Jan Brugge-Oostende AV
Site Coordinator
+32 50453166
Belgium Gent 9000 Universitair Ziekenhuis Gent
Site Coordinator
+32 93321487
Belgium Yvoir 5530 UCL Mont-Godinne
Site Coordinator
+32 81423831
Bulgaria Pleven 5800 University Multiprofile Hospital for Active Treatment "Dr. G. Stranski" EAD
Site Coordinator
+359 64886390
Bulgaria Sofia 1000 University Multiprofile Hospital for Active Treatment "Sveti Georgi" EAD
Site Coordinator
+359 28953135
Canada Alberta Calgary T2N 4N2 Tom Baker Cancer Centre
Site Coordinator
403-521-3431
Canada Alberta Edmonton T6G-3G3 University of Alberta Hospital
Site Coordinator
780-432-8757
Canada British Columbia Vancouver V5Z 1M9 Vancouver General Hospital (VGH)
Site Coordinator
604-875-5649
Canada Ontario Toronto M5G 1X5 Princess Margaret Cancer Centre
Site Coordinator
416-581-7849
Croatia Zagreb 10000 Klinička Bolnica Dubrava
Site Coordinator
+385 14884391
Croatia Zagreb 10000 Klinička Bolnica Merkur
Site Coordinator
+385 12253222
Croatia Zagreb 10000 Klinički Bolnički Centar Zagreb
Site Coordinator
+385 14884391
Czechia Hradec Kralove 500 05 Fakultní Nemocnice Hradec Králové
Site Coordinator
+420 495833795
Czechia Olomouc 775 20 Fakultní Nemocnice Olomouc
Site Coordinator
+420 588442849
Czechia Ostrava 708 52 Fakultní Nemocnice Ostrava
Site Coordinator
+420 597374278
Czechia Pilsen 304 60 Fakultni Nemocnice Plzen
Site Coordinator
+420 377103722
Czechia Praha 2 128 20 Vseobecna Fakultni Nemocnice, Ustav hematologie a krevni transfuze (UHKT)
Site Coordinator
+420 221977182
France Grenoble 38043 Hospital A. Michallon
Site Coordinator
+33 476769241
France Le Chesnay 78150 Centre Hospitalier de Versailles - Hôpital André Mignot
Site Coordinator
+33 139638319
France Le Mans 72037 Centre Hospitalier du Mans
Site Coordinator
+33 243434343
France Lille 59037 Centre Hospitalier Régional Universitaire de Lille (CHRU) - Hôpital Claude Huriez
Site Coordinator
+33 320445718
France Lyon 69373 Centre Léon Bérard
Site Coordinator
+33 426556802
France Marguerittes 13009 L'Institut Paoli - Calmettes
Site Coordinator
+33 491223450
France Marseille 13385 Hôpital de la Conception
Site Coordinator
+33 491381962
France Montpellier 34295 CHRU Montpellier - Saint Eloi
Site Coordinator
+33 467336155
France Paris 75012 Hôpital Saint-Antoine
Site Coordinator
+33 149283274
France Paris 75475 Hôpital Saint-Louis
Site Coordinator
+33 171207008
France Pessac 33604 Hôpital Haut-Lévêque
Site Coordinator
+33 557656511
France Pierre Benite 69495 Centre Hospitalier Lyon-Sud
Site Coordinator
+33 478864368
France Rouen 76038 Centre Henri Becquerel - Centre de Lutte Contre le Cancer
Site Coordinator
+33 232082909
France Toulouse 31059 Centre Hospitalier Universitaire de Toulouse - Hôpital Purpan
Site Coordinator
+33 531156288
Germany Bad Saarow 15526 HELIOS Klinikum Bad Saarow
Site Coordinator
+49 3363173527
Germany Berlin 10117 Charité - Universitätsmedizin Berlin
Site Coordinator
+49 30450517222
Germany Braunschweig 38114 Städtisches Klinikum Braunschweig gGmbH
Site Coordinator
+49 5315953700
Germany Düsseldorf 40479 Marien Hospital Düsseldorf GmbH
Site Coordinator
+49 21144002079
Germany Essen 45122 Universitätsklinikum Essen
Site Coordinator
+49 2017231861
Germany Frankfurt am Main 60590 Universitätsklinikum Frankfurt
Site Coordinator
+49 6963016365
Germany Halle 6120 Universitätsklinikum Halle (Saale)
Site Coordinator
+49 3455572849
Germany Hamburg 22083 Universitätsklinikum Hamburg-Eppendorf (UKE)
Site Coordinator
+49 40202299240
Germany Hamm 59063 Evangelisches Krankenhaus Hamm gGmbH
Site Coordinator
+49 23819058325
Germany Hannöver 30625 Medizinische Hochschule Hannover (MHH)
Site Coordinator
+49 5115329321
Germany Heidelberg 69115 Universitätsklinikum Münster
Site Coordinator
+49 622133820
Germany Heidelberg 69115 Universitätsklinikum Tübingen
Site Coordinator
+49 622133820
Germany Heidelberg 69120 Universitätsklinikum Heidelberg
Site Coordinator
+49 6221568803
Germany Herne 44625 Marien Hospital Herne
Site Coordinator
+49 23234991579
Germany Leipzig 4103 Universitätsklinikum Leipzig
Site Coordinator
+49 3419713132
Germany Mainz 55131 Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Site Coordinator
+49 6131175950
Germany Mutlangen 73557 Stauferklinikum Schwäbisch Gmünd
Site Coordinator
+49 71717011302
Germany Wuppertal 42283 HELIOS Klinikum Wuppertal
Site Coordinator
+49 2028962396
Hong Kong Hong Kong Prince of Wales Hospital
Site Coordinator
+852 35053120
Hong Kong Hong Kong Queen Mary Hospital
Site Coordinator
+852 22556729
Hungary Budapest 1051 Markusovszky Egyetemi Oktatókórház
Site Coordinator
+36 17951195
Hungary Budapest 1051 Szegedi Tudományegyetem
Site Coordinator
+36 17951195
Hungary Budapest 1083 Semmelweis Egyetem
Site Coordinator
+36 12100279
Hungary Debrecen 4032 Debreceni Egyetem Klinikai Központ
Site Coordinator
+36 205280601
Hungary Pécs 7624 Pecsi Tudomanyegyetem Klinikai Központ
Site Coordinator
+36 72536000
Hungary Szombathely 9700 Markusovszky Egyetemi Oktatókórház Belgyógyászati és Onkohaematológiai Centrum
Site Coordinator
+36 0694311542
Israel Tsifrin Be'er Ya'aqov 70300 Assaf Harofeh Medical Center
Site Coordinator
+972 89779762
Israel Haifa 31048 Bnai Zion Medical Center
Site Coordinator
+972 48359754
Israel Haifa 31096 Rambam Medical Center
Site Coordinator
+972 48542547
Israel Jerusalem 91120 Hadassah University Medical Center
Site Coordinator
+972 5328466
Israel Petaẖ Tiqwa 49100 Rabin Medical Center - Beilinson Hospital
Site Coordinator
+972 39378008
Israel Ramat-Gan 52621 The Chaim Sheba Medical Center
Site Coordinator
+972 3530233 ext. 7
Israel Tel Aviv 64239 Tel Aviv Sourasky Medical Center
Site Coordinator
+972 36973912
Italy Alessandria 15121 Azienda Ospedaliera Nazionale SS.Antonio e Biagio e Cesare Arrigo
Site Coordinator
+39 0131206613
Italy Bologna 40138 Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi
Site Coordinator
+39 0516363829
Italy Cagliari 9121 AO Brotzu - Ospedale Oncologico "Businco"
Site Coordinator
+39 0706095316
Italy Genova 16132 IRCCS AOU San Martino - IST
Site Coordinator
+39 0105555482
Italy Milano 20162 ASST Grande Ospedale Metropolitano Niguarda
Site Coordinator
+39-0264443651
Italy Napoli 80131 A.O.R.N. "A. Cardarelli"
Site Coordinator
+39 0817472401
Italy Novara 28100 Azienda Ospedaliero Universitaria Maggiore della Carità di Novara
Site Coordinator
+39 03213733081
Italy Orbassano (TO) 10043 Azienda Ospedaliero - Universitaria San Luigi Gonzaga
Site Coordinator
+39 0119026709
Italy Palermo 90146 Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello
Site Coordinator
+39 0916802682
Italy Roma 133 Fondazione Policlinico Universitario Agostino Gemelli
Site Coordinator
+39 0620900035
Italy Roma 133 Ospedale S. Eugenio
Site Coordinator
+39 0620900035
Italy Roma 133 Policlinico Tor Vergata
Site Coordinator
+39 0620900035
Italy Roma 20132 IRCCS Ospedale San Raffaele
Site Coordinator
+39 0620900035
Italy Roma 50134 Azienda Ospedaliero-Universitaria Careggi
Site Coordinator
+39 0620900035
Italy Roma 56126 Azienda Ospedaliero Universitaria Pisana - Ospedale Santa Chiara
Site Coordinator
+39 0620900035
Italy Roma 80131 Azienda Ospedaliera Universitaria "Federico II"
Site Coordinator
+39 0620900035
Italy Rozzano 20089 Istituto Clinico Humanitas
Site Coordinator
+39 0282244080
Italy Siena 53100 Azienda Ospedaliera Universitaria Senese
Site Coordinator
+39 0577585112
Italy Torino 10126 Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino - Ospedale Molinette
Site Coordinator
+39 0116334229
Italy Torino 10128 Azienda Ospedaliera Ordine Mauriziano di Torino
Site Coordinator
+39 0115082224
Italy Varese 21100 ASST dei Sette Laghi - Ospedale di Circolo e Fondazione Macchi Varese
Site Coordinator
+39 0332278761
Korea, Republic of Busan 48108 Inje University Haeundae Paik Hospital
Site Coordinator
+82 517970001
Korea, Republic of Busan 49241 Pusan National University Hospital
Site Coordinator
+82 512407899
Korea, Republic of Daegu 41944 Kyungpook National University Hospital
Site Coordinator
+82 534206357
Korea, Republic of Daegu 42415 Yeungnam University Medical Center
Site Coordinator
+82 536203082
Korea, Republic of Daegu 42472 Daegu Catholic University Medical Center
Site Coordinator
+82 536293062
Korea, Republic of Hwasun 58128 Chonnam National University Hwasun Hospital
Site Coordinator
+82 613797637
Korea, Republic of Incheon 21565 Gachon University Gil Hospital
Site Coordinator
+82 1033958656
Korea, Republic of Seongnam-si 13620 Seoul National University Bundang Hospital
Site Coordinator
+82 317873942
Korea, Republic of Seoul 3080 Seoul National University Hospital
Site Coordinator
+82 220727450
Korea, Republic of Seoul 3722 Severance Hospital
Site Coordinator
+82 222280513
Korea, Republic of Seoul 4401 SoonChunHyang University Seoul Hospital
Site Coordinator
+82 27099203
Korea, Republic of Seoul 5030 Konkuk University Medical Center
Site Coordinator
+82 220307747
Korea, Republic of Seoul 5505 Asan Medical Center
Site Coordinator
+82 230107283
Korea, Republic of Seoul 6351 Samsung Medical Center
Site Coordinator
+82 221487390
Korea, Republic of Seoul 6591 The Catholic University of Korea, Seoul St. Mary's Hospital
Site Coordinator
+82 222582542
Korea, Republic of Seoul 8308 Korea University Guro Hospital
Site Coordinator
+82 226261624
Korea, Republic of Sŏwŏn 16499 Ajou University Hospital
Site Coordinator
+82 312195569
Korea, Republic of Ulsan 44033 Ulsan University Hospital (UUH)
Site Coordinator
+82 522508537
Poland Kraków 31-501 Szpital Uniwersytecki w Krakowie
Site Coordinator
+48 124247426
Poland Słupsk 76-200 Wojewódzki Szpital Specjalistyczny im. Janusza Korczaka
Site Coordinator
+48 598460390
Poland Warszawa 00-957 Instytut Hematologii i Transfuzjologi
Site Coordinator
+48 223496676
Poland Warszawa 50367 Samodzielny Publiczny Szpital Kliniczny Nr. 1 we Wrocławiu
Site Coordinator
+48 223496472
Portugal Coimbra 3000-075 Centro Hospitalar e Universitário de Coimbra, EPE - Hospitais da Universidade de Coimbra
Site Coordinator
+351 911956157
Portugal Porto 4099-001 Centro Hospitalar do Porto, EPE - Hospital Geral de Santo António
Site Coordinator
+351 222077500
Portugal Porto 4200-072 Instituto Português Oncologia do Porto Francisco Gentil, EPE
Site Coordinator
+351 925036044
Portugal Porto 4200-319 Centro Hospitalar de São João, EPE - Hospital de São João
Site Coordinator
+351 225512143
Romania Bucuresti 20125 Institutul Regional de Oncologie Iași
Site Coordinator
+40 212102880
Romania Bucuresti 20125 Spitalul Clinic Colentina
Site Coordinator
+40 212102880
Romania Bucuresti 20125 Spitalul Clinic Coltea
Site Coordinator
+40 212102880
Romania Bucuresti 20125 Spitalul Universitar de Urgenta Bucuresti
Site Coordinator
+40 212102880
Romania Cluj-Napoca 400124 Institutul Oncologic "Prof. Dr. Ion Chiricuţă" Cluj Napoca
Site Coordinator
+40 741416198
Romania Târgu-Mureş 540042 Spitalul Clinic Judetean de Urgenta Tîrgu - Mures
Site Coordinator
+40 755 037 754
Russian Federation Penza 440071 Penza Regional Oncology Dispensary
Site Coordinator
+7 9053672147
Russian Federation Ryazan' 390039 Ryazan Regional Clinical Hospital
Site Coordinator
+7 4912214157
Russian Federation Saratov 410012 Saratov State Medical University named after V.I. Razumovsky
Site Coordinator
+7 8452273370
Russian Federation St. Petersburg 191024 Russian Research Institute of Hematology and Blood Transfusion
Site Coordinator
+7 9112731583
Russian Federation St. Petersburg 194291 Leningrad Regional Clinic and Hospital
Site Coordinator
+7 964323431
Russian Federation Tula 300053 Tula Regional Clinical Hospital
Site Coordinator
+7 953192945 ext. 2
Serbia Belgrade 11000 Klinički Centar Srbije
Site Coordinator
+381 638151427
Serbia Nis 18000 Klinički Centar Niš
Site Coordinator
+381 641562762
Serbia Novi Sad 21101 Klinički Centar Vojvodine
Site Coordinator
+381 642032076
Singapore Singapore 119074 National University Hospital (S) Pte Ltd
Site Coordinator
+65 67795555
Singapore Singapore 138543 Singapore General Hospital
Site Coordinator
+65 64713266
Spain Mallorca Palma 7014 Hospital Universitari Son Espases
Site Coordinator
+34 871205000
Spain Alicante 3010 Hospital General Universitario de Alicante
Site Coordinator
+34 661502279
Spain Badalona 8916 Catalan Institute of Oncology (ICO)
Site Coordinator
+34 934978574
Spain Barcelona 8003 Hospital del Mar
Site Coordinator
+34 932483106
Spain Barcelona 8035 Hospital Universitario Vall d'Hebron
Site Coordinator
+34 932746247
Spain Barcelona 8036 Hospital Clinic i Provincial
Site Coordinator
+34 932275786
Spain Barcelona 8907 Hospital Duran i Reynals
Site Coordinator
+34 932607750
Spain Bilbao 48013 Hospital de Basurto
Site Coordinator
+34 944006001
Spain Cáceres 10002 Hospital San Pedro de Alcántara
Site Coordinator
+34 927256234
Spain Córdoba 14004 Hospital Universitario Reina Sofía
Site Coordinator
+34 697959354
Spain Granada 18014 Complejo Hospitalario Universitario Granada
Site Coordinator
+34 958020147
Spain Madrid 28007 Hospital General Universitario Gregorio Marañón
Site Coordinator
+34 915868394
Spain Madrid 28034 Hospital Universitario Ramón y Cajal
Site Coordinator
+34 913 368 686
Spain Madrid 28040 Hospital Clínico San Carlos
Site Coordinator
+34 913303000
Spain Madrid 28041 Hospital Universitario 12 de Octubre
Site Coordinator
+34 917792809
Spain Madrid 28223 Hospital Quirón Madrid
Site Coordinator
+34 696591731
Spain Majadahonda 28222 Hospital Universitario Puerta de Hierro - Majadahonda
Site Coordinator
+34 911917650
Spain Málaga 29010 Hospital Regional Universitario de Málaga - Hospital General
Site Coordinator
+34 951291987
Spain Oviedo 33011 Hospital Universitario Central de Asturias
Site Coordinator
+34 952108000
Spain Pamplona 31008 Complejo Hospitalario de Navarra
Site Coordinator
+34 848425002
Spain Pamplona 31008 Fundación Jiménez Díaz
Site Coordinator
+34 848422495
Spain Pamplona 31008 Hospital Clínico Universitario "Lozano Blesa"
Site Coordinator
+34 848422495
Spain Pamplona 31008 Hospital General Universitario Morales Meseguer
Site Coordinator
+34 848422495
Spain Pamplona 31008 Hospital Universitario Miguel Servet
Site Coordinator
+34 848422495
Spain Pamplona 31008 Hospital Álvaro Cunqueiro
Site Coordinator
+34 848422495
Spain Salamanca 37007 Hosp Universitario Salamanca
Site Coordinator
+34 923291100
Spain Santander 39008 Hospital Universitario Marqués de Valdecilla
Site Coordinator
+34 942202573
Spain Santiago de Compostela 15706 Complexo Hospitalario Universitario de Santiago (CHUS) - Hospital Clínico Universitario
Site Coordinator
+34 981951469
Spain Sevilla 41013 Hospital Universitario Virgen del Rocío (2)
Site Coordinator
+34 955013273
Spain Sevilla 41013 Hospital Universitario Virgen del Rocío
Site Coordinator
+34 955013622
Spain Tarragona 43005 Hospital Universitari Joan XXIII de Tarragona
Site Coordinator
+34 977295821
Spain Valencia 46010 Hospital Clinico Universitario de Valencia
Site Coordinator
+34 961973500
Spain Valencia 46017 Hospital Universitario Dr. Peset
Site Coordinator
+34 961622532
Spain Valencia CP 46026 Hospital Universitari i Politècnic La Fe
Site Coordinator
+34 96244980
Taiwan Niaosong District Kaohsiung 83301 Chang Gung Medical Foundation - Kaohsiung Branch
Site Coordinator
+886 77317123
Taiwan Taichung 40447 China Medical University Hospital
Site Coordinator
+886 422052121
Taiwan Tainan 704 National Cheng Kung University Hospital
Site Coordinator
+886 62353535
Taiwan Taipei 100 National Taiwan University Hospital
Site Coordinator
+886 223123456
Taiwan Taipei 11217 Taipei Veterans General Hospital
Site Coordinator
+886 228712121
Taiwan Taoyuan 33305 Chang Gung Medical Foundation - Linkou Branch
Site Coordinator
+886 33281200
Ukraine Poltava 36011 Poltava Regional Clinical Hospital named after M. V. Sklifosovskoho
Site Coordinator
+380 972191994
Ukraine Vinnytsia 21018 Vinnitsa Regional Clinical Hospital im. N.I. Pirogov
Site Coordinator
+380 432661557
Ukraine Zhytomyr 10002 Zhitomir Regional Clinical Hospital
Site Coordinator
+380 412342488
United Kingdom Canterbury CT1 3NG East Kent Hospitals University NHS Foundation Trust - Kent and Canterbury Hospital
Site Coordinator
+44 1227865323
United Kingdom Maidstone ME16 9QQ Maidstone and Tunbridge Wells NHS Trust - Maidstone Hospital
Site Coordinator
+44 1622224439

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