Clinical Trial Details

NCT ID: NCT02060383
Date Last Changed: October 12, 2017


Research Study Summary

A clinical research study for the treatment of Cushing's Disease, or Acromegaly

Research Study Title

A Multi-center, Randomized, Open-label, Phase IV Study to Investigate the Management of Pasireotide-induced Hyperglycemia With Incretin Based Therapy or Insulin in Adult Patients With Cushing's Disease or Acromegaly


The study aims to demonstrate that pasireotide-induced hyperglycemia can be effectively and safely managed in majority of patients, including those with diabetes at start of pasireotide treatment.

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Recruitment Details

18 and up
Overall Status
Lead Sponsor
Novartis Pharmaceuticals
49 Months
Facility Type


All ages 18 Years and up

Inclusion Criteria:

  • Patients greater than or equal to 18 years old

  • Confirmed diagnosis of Cushing's disease or acromegaly

Exclusion Criteria:

  • Patients who require surgical intervention

  • Patients receiving DPP-4 inhibitors or GLP-1 receptor agonists within 4 weeks prior to study entry

  • HbA1c > 10 % at screening

  • Known hypersensitivity to somatostatin analogues Other protocol-defined inclusion/exclusion criteria may apply.

Site Locations (15)

Country State City Zip Facility and Contact
United States California Multiple Locations Diabetes and Endocrine Associates La Mesa Location
Denise Humphries

Raymond Fink
Principal Investigator
United States California Torrance 90502 LA Biomedical Research at Harbor UCLA Medical Center SC - SOM230B2219
Elizabeth Ruiz

Ronald Swerdloff
Principal Investigator
United States California Ventura 93003 Coastal Metabolic Research Centre SC
Gabriel Garcia

Ronald H. Chochinov
Principal Investigator
United States Florida Jacksonville 32223 East Coast Institute for Research East Coast Inst. for Res(ECIR)
Miriam Green

Mae Sheikh-Ali
Principal Investigator
United States Missouri Saint Louis 63110 Washington University SC - SOM230B2411
Mary Jane Clifton

Julie Silverstein
Principal Investigator
United States Montana Great Falls 59405 Great Falls Clinic Great Falls Clinic
Patty Bowman

Barry Cohan
Principal Investigator
United States New Jersey New Brunswick 08901 Robert Wood Johnson Medical School - Rutgers SC
Deborah A. McCloskey

Sara Lubitz
Principal Investigator
United States New York New York 10029 The Mount Sinai Hospital SC
Vanessa L Cohen

Eliza B. Geer
Principal Investigator
United States New York New York 10032 Columbia University Medical Center- New York Presbyterian Neuroendocrine Unit
Carlos C. Reyes-Vidal

Pamela U. Freda
Principal Investigator
United States New York New York 10075 Lenox Hill Hospital/Manhattan Eye, Ear and Throat Hospital SC
Tamika Wong

John Boockvar
Principal Investigator
United States Pennsylvania Pittsburgh 15212 Allegheny Endocrinology Associates SC
Ann Minnock

Murray B Gordon
Principal Investigator
United States Tennessee Nashville 37212-8210 Vanderbilt Clinical Trials Center SOM230B2219
Sheri L. Dixon

Andrea L. Utz
Principal Investigator
United States Texas Houston 77030 Baylor College of Medicine Ben Taub General Hosp.
Betsy Staudinger

Susan L. Samson
Principal Investigator
United States Virginia Chesapeake 23321 Virginia Endocrinology Research SC-2
Vicki M. Maine

James LaRocque
Principal Investigator
United States Washington Seattle 98122-4379 Swedish Medical Center Dept.ofSeattle Neuroscience(2)
Yuriko Courtney

Zachary Litvak
Principal Investigator


Novartis Pharmaceuticals

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