Clinical Trial Details

NCT ID: NCT01705626
Date Last Changed: May 10, 2017

Overview

Research Study Summary

Screening for the Transthyretin-Related Familial Amyloidotic Small Fiber Polyneuropathy

Research Study Title

TTR-FAP Screening - Screening for the Transthyretin-Related Familial Amyloidotic Small Fiber Polyneuropathy - a International, Multicentre, Epidemiological Protocol

Purpose

The purpose of this study is to determine the prevalence of patients with a polyneuropathy of undetermined etiology based on the normal results of laboratory data (CRP, glucose, electrolytes, urea,transaminases, TSH, immunoglobulins, vitamin B12, RF, ANA, antibodies against Lyme borrelia) no anamnesis for carcinoma, no continuous alcohol consumption; no light-chain-amyloidosis; no anamnesis for heavy metal exposure.

To Learn more

Recruitment Details

Gender
All
Age
18 and up
Overall Status
Recruiting
Lead Sponsor
University of Rostock
Duration
36 Months
Facility Type
N/A
Compensation

Eligibility

All ages 18 Years and up

Inclusion Criteria:

  • Informed consent will be obtained from the patient before any study related procedures

  • Patients aged older than 18 years

  • Patients with small fiber polyneuropathy of undetermined etiology based on:the normal results of laboratory data (CRP, glucose, electrolytes, urea,transaminases, TSH, immunoglobulins, vitamin B12, RF, ANA, antibodies against Lyme borrelia)

  • No anamnesis for carcinoma

  • No continuous alcohol consumption

  • No light-chain-amyloidosis

  • No anamnesis for heavy metal exposure

  • Progressive idiopathic small fiber polyneuropathy

  • Presence of an electrophysiological examination for N. Peroneus and N. Suralis

Exclusion Criteria:

  • No Informed Consent from the patient before any study related procedures

  • Patients younger than 18 years

  • The etiology of the small fiber polyneuropathy is already known based on:

  • significant pathological results for any of the following laboratory data (CRP, glucose, electrolytes, urea, transaminases, TSH, immunoglobulins, vitamin B12, RF, ANA, antibodies against Lyme borrelia)

  • Positive anamnesis for carcinoma

  • Continuous alcohol consumption

  • Light-chain-amyloidosis

  • Anamnesis for heavy metal exposure

  • No progression of idiopathic small fiber polyneuropathy within the last two years

  • No presence of an electrophysiological examination for N. Peroneus and N. Suralis

Site Locations (1)

Country State City Zip Facility and Contact
Germany Rostock 18147 Albrecht-Kossel-Institute for Neuroregeneration (AKos) Centre for Mental Health Disease University of Rostock
Arndt Rolfs, Prof.
+49 381 494 ext. 9540
arndt.rolfs@med.uni-rostock.de

Contact

Arndt Rolfs, MD
49-381-494 ext. 9540
E-mail:

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