Clinical Trials Resource Center

Clinical Trial Details

NCT ID: NCT01453803
Date Last Changed: September 19, 2016

Overview

Research Study Summary

A clinical research study of Harvesting and Implantation of Adipose-Derived Stem Cells for the treatment of Parkinson's Disease

Research Study Title

An Open-label, Non-Randomized, Multi-Center Study to Assess the Safety and Effects of Autologous Adipose-Derived Stromal Cells Delivered Intravenously and Intranasally in Patients With Parkinson's Disease

Purpose

The intent of this clinical study is to answer the questions:

  1. Is the proposed treatment safe

  2. Is treatment effective in improving the disease pathology of patients with Parkinson's Disease and clinical outcomes.

To Learn more

Recruitment Details

Phase
1/2
Gender
All
Age
18 to 80 Years
Overall Status
Recruiting
Lead Sponsor
Ageless Regenerative Institute
Duration
42 Months
Facility Type
N/A
Compensation

Eligibility

All ages 18 Years to 80 Years

Inclusion Criteria:

  • Males and Females between Age 18 and 80 years.

  • Patient with current diagnosis of PD with motor complications (as confirmed by neurologist) as per the standard criteria and guidelines.

  • Responsiveness to Levodopa or dopa agonist. This is defined as improvement between Off and On UPDRS by at least 33% of the Motor UPDRS.

  • PD of Stage 2.5, 3 & 4 of HOEHN & YAHR staging.

  • Stable Parkinsonian medications for the 60 days prior to the surgical therapy.

  • MRI not showing gross atrophy or any other pathology of brain.

  • Patients with score less than 19 for the Montgomery-Asberg Rating Scale (MADRS) for Depression.

  • NO Significant cognitive impairment.MMSE > 21.

  • Up to date on all age and gender appropriate cancer screening per American Cancer Society

Exclusion Criteria:

  • History of intracranial surgeries or implantation of a device for Parkinson's disease two years prior to treatment.

  • History of psychiatric disorders like schizophrenia or psychotic disorders.

  • History of other malignancy, with the exception of treated cutaneous squamous cell or basal cell carcinoma, within 5 years.

  • Contraindication for MRI

  • Females who are pregnant or nursing or females of childbearing potential who are unwilling to maintain contraceptive therapy for the duration of the study

  • Life expectancy < 6 months due to concomitant illnesses.

  • Exposure to any investigational drug or procedure within 1 month prior to study entry or enrolled in a concurrent study that may confound results of this study.

  • Active infectious disease. Patients known to have tested positive for HIV, HTLV, HBV, HCV, CMV (IgM > IgG) and/or syphilis will be evaluated by an expert as to patient eligibility based on the patient's infectious status

  • Any illness which, in the Investigator's judgement, will interfere with the patient's ability to comply with the protocol, compromise patient safety, or interfere with the interpretation of the study results

  • Patients on chronic immunosuppressive transplant therapy

  • Systolic blood pressure (supine) ≤90 mmHg;

  • Resting heart rate > 100 bpm;

  • Active clinical infection being treated by antibiotics within one week of enrollment.

  • Known drug or alcohol dependence or any other factors which will interfere with the study conduct or interpretation of the results or who in the opinion of the investigator are not suitable to participate.

  • History of cancer (other than non-melanoma skin cancer or in-situ cervical cancer) in the last two years.

  • Unwilling and/or not able to give written informed consent.

Site Locations (1)

Country State City Zip Facility and Contact
United States Florida Aventura 33180 Ageless Regenerative Institute LLC
Sharon A McQuillan, MD
305-933-2988
clinicaltrials@agelessinstitute.com

Sharon McQuillan, MD
Principal Investigator

Contact

Janette M Daher
9547447400 ext. 2727
E-mail:

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