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Clinical Trial Details


Research Study Summary

A clinical research study for the treatment of Anesthesia or Neuromuscular Blockade

Research Study Title

The Effect of Rocuronium on the Response of Composite Variability Index (CVI) to Laryngoscopy


The Bispectral Index monitor is used in many operating rooms to provide information to the anesthesiologist about a patient's level of consciousness. The Composite Variability Index, or Composite Variability Index (CVI), is a new index that may provide the anesthesiologist with more information about the condition of the patient. The purpose of this study is to determine if a commonly used anesthetic drug (rocuronium) affects the CVI measurement differently with different doses. Rocuronium is a muscle relaxant routinely used during surgery. It is expected that the group given the highest dose of rocuronium will have diminished CVI values.

To Learn more

Both Male and Female


18 to 75 Years

Overall Status


Lead Sponsor



27 Months

Facility Type



Both Male and Female ages 18 Years to 75 Years

Inclusion Criteria:

  • Presence of ASA physical status class I or II. (This will exclude subjects with significant medical problems).

  • Body mass index between 18 and 35 kg m-2.

  • No use of psychotropic or neuropsychiatric medications.

  • A airway assessment with no indication of a difficult intubation including a class I or II Mallampati airway and a mandible-to-hyoid distance of greater than three fingerbreadths.

  • Age between 18-75 years.

Exclusion Criteria:

  • Does not meet inclusion criteria.

Site Locations (1)

Country State City Zip Facility and Contact
United States Vermont Burlington 05405 Fletcher Allen Health Care

Donald Mathews, MD
Principal Investigator


Jacquelyn Conace

NCT ID: NCT01450813

Date Last Changed: June 5, 2013

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