Clinical Trial Details

NCT ID: NCT01122095
Date Last Changed: May 28, 2010

Overview

Research Study Summary

Patients are needed to participate in a clinical research study for the treatment of Psoriasis, Obesity, Cardiovascular Risk or Inflammation

Research Study Title

Cross-sectional Evaluation of Biological Markers of Cardiovascular Disease in Children and Adolescents With Psoriasis

Purpose

Hypothesis 1: Patients with psoriasis will have clinical and laboratory assessments differing from control patients.

Hypothesis 2: Patients with psoriasis will have laboratory alterations that correlate with other clinical characteristics of their psoriasis.

To Learn more

Recruitment Details

Gender
Both Male and Female
Age
Up to 18 Years
Overall Status
Recruiting
Lead Sponsor
University of California, San Diego
Duration
Facility Type
N/A
Compensation

Eligibility

Both Male and Female ages up to 18 Years

Inclusion Criteria:

Subjects of any race or ethnicity who meet all of the following criteria are eligible for enrollment into the study:

  1. The subject has a diagnosis of typical psoriasis, with or without arthritis, based on the clinical evaluation by an investigator or a prior diagnosis by a pediatric dermatologist

  2. Persons residing in the US.

  3. Subjects 0 to 18 years of age.

  4. Subjects/Guardians willing and able to comply with the requirements of the study.

  5. Subjects/Guardians willing and able to give informed consent.

  6. The subject is in general good health in the opinion of the investigator.

Exclusion Criteria:

  1. Over 18 years of age.

  2. Subject has had a diagnosis of congenital heart disease.

  3. Subject has had any cardiac catheterizations or surgeries.

  4. Subject has taken any cardiac medications (calcium channel blockers, beta blockers, vasotropic medicines) within the past 2 years.

  5. Subjects determined to have atypical psoriasis or isolated palmoplantar psoriasis.

  6. Subject diagnosed with any other systemic inflammatory disease including atopic dermatitis, severe acne vulgaris, inflammatory bowel disease, juvenile idiopathic arthritis, connective tissue disease and other similar conditions.

  7. Having autoimmune or immunodeficiency disease.

  8. Presence of active systemic fungal, bacterial, or viral infections.

  9. Presence of active systemic malignancy.

  10. Mental illness or history of drug or alcohol abuse that, in the opinion of the investigator, would interfere with the participant's ability to comply with study requirements.

  11. Inability or unwillingness of a participant to give written informed consent.

Control Inclusion Criteria:

  1. Age up to 18 years.

  2. Ability and willingness to provide informed consent.

Control Exclusion Criteria:

  1. Over 18 years of age.

  2. Subject has had a diagnosis of congenital heart disease.

  3. Subject has had any cardiac catheterizations or surgeries.

  4. Subject has taken any cardiac medications (calcium channel blockers, beta blockers, vasotropic medicines) within the past 2 years.

  5. Subjects determined to have psoriasis of any type or a family history (first degree relative) with psoriasis.

  6. Subject diagnosed with any other systemic inflammatory disease including atopic dermatitis, severe acne vulgaris, inflammatory bowel disease, juvenile idiopathic arthritis, connective tissue disease and other similar conditions.

  7. Having autoimmune or immunodeficiency disease.

  8. Presence of active systemic fungal, bacterial, or viral infections.

  9. Presence of active systemic malignancy.

  10. Mental illness or history of drug or alcohol abuse that, in the opinion of the investigator, would interfere with the participant's ability to comply with study requirements.

  11. Inability or unwillingness of a participant to give written informed consent.

Site Locations (1)

Country State City Zip Facility and Contact
United States California San Diego 92123 Rady Children's Hospital Dermatolgoy
Donna Pascual, LVN
858-576-1700 ext. 4295
dpascual@rchsd.org

Wynnis Tom, MD
Sub-Investigator

Contact

Lawrence F. Eichenfield, MD
858-966-1700
E-mail:

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